ABSTRACT
Cerebral toxoplasmosis and cytomegalovirus (CMV) infection are very frequent in AIDS. Biological markers of toxoplasmosis and CMV were studied in blood and cerebrospinal fluid (CSF) of 121 HIV-positive and 35 HIV-negative patients in the Central Hospital of the Congolese Army in Brazzaville. In the case of clinically suspected cerebral toxoplasmosis, the simultaneous presence of specific IgG antibodies in the blood and in the CSF can be considered as having complementary diagnostic value (PPV = 63.3%, NPV = 89.9%). The symptomatology of AIDS is very polymorphous and includes various etiological factors; as a result it is very difficult to estimate the responsibility of cytomegalovirus in the absence of positive viral culture, even with the simultaneous presence of specific IgG antibodies in the blood and CSF (PPV = 75.7%, NPV = 54.6%).
Subject(s)
AIDS-Related Opportunistic Infections/epidemiology , Antibodies, Protozoan/blood , Antibodies, Viral/blood , Cytomegalovirus Infections/epidemiology , Cytomegalovirus/immunology , HIV-1 , Immunoglobulin G/blood , Population Surveillance , Toxoplasma/immunology , Toxoplasmosis, Cerebral/epidemiology , AIDS-Related Opportunistic Infections/blood , AIDS-Related Opportunistic Infections/cerebrospinal fluid , AIDS-Related Opportunistic Infections/complications , Adolescent , Adult , Aged , Animals , Antibodies, Protozoan/cerebrospinal fluid , Antibodies, Viral/cerebrospinal fluid , Biomarkers/blood , Biomarkers/cerebrospinal fluid , Congo/epidemiology , Cytomegalovirus Infections/blood , Cytomegalovirus Infections/cerebrospinal fluid , Cytomegalovirus Infections/complications , Female , Humans , Immunoglobulin G/cerebrospinal fluid , Male , Middle Aged , Prevalence , Sensitivity and Specificity , Seroepidemiologic Studies , Toxoplasmosis, Cerebral/blood , Toxoplasmosis, Cerebral/cerebrospinal fluid , Toxoplasmosis, Cerebral/complicationsABSTRACT
From the 24 March 1988 to the 15 June 1989, we noticed the peripheric and medullar haematologic modifications of 46 patients infected by HIV, classified in the group IV of CDC. The haematologic modifications found are: a peripheric cytopenia with a constant anemia often serious, a leuconeutropenia, a mild or missing lymphopenia. In comparison: the bone marrow is often rich in the different lineage with more often a sharp lymphoplasmocytal reaction, sometime very characteristic on the cytological side. 2 myeloid leukemia were diagnosed by participation of the myelogram. At least, the proteinogram showed a major polyclonal hypergammaglobulinemy sometimes monoclonal.
