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Chem Biodivers ; 18(12): e2100499, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34761862

ABSTRACT

A new natural Diels-Alder adduct (3) was isolated from the leaves and stem bark of Artocarpus integer, along with seventeen known compounds (1, 2, and 4-18). Structural elucidation was conducted using NMR and HR-ESI-MS data, and comparisons were made with previous studies. Deoxyartonin I (3) exhibited the most potent α-glucosidase inhibition (IC50 7.80±0.1 µM), outperforming the acarbose positive control. This was mixed-mode inhibition, as indicated by the intersect in the second quadrant of each respective plot. An in silico molecular docking model and the pharmacokinetic features of 3 suggest that it is a potential inhibitor of enzyme α-glucosidase, and is therefore a lead candidate as a drug against diabetes mellitus.


Subject(s)
Artocarpus/chemistry , Glycoside Hydrolase Inhibitors/pharmacology , Molecular Docking Simulation , Plant Extracts/pharmacology , alpha-Glucosidases/metabolism , Dose-Response Relationship, Drug , Glycoside Hydrolase Inhibitors/chemistry , Glycoside Hydrolase Inhibitors/isolation & purification , Humans , Plant Components, Aerial/chemistry , Plant Extracts/chemistry , Plant Extracts/isolation & purification
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