Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Nat Prod Res ; 33(13): 1903-1908, 2019 Jul.
Article in English | MEDLINE | ID: mdl-29806497

ABSTRACT

From an EtOAc-soluble fraction of the leaves of Azadirachta indica, one new lactam 28-norlimonoid named nimbandiolactam-21 (1), together with 2 known limonoids (2 and 3) were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Nimbandiolactone-23 (2) showed the most potent α-glucosidase inhibitory activity, with an IC50 value of 38.7 µM. Compound 1 represents the first naturally occurring example of a 28-norlimonoid having the lactam moiety. The plausible biosynthetic pathway for the formation of lactam moiety in 1 was proposed.


Subject(s)
Azadirachta/chemistry , Glycoside Hydrolase Inhibitors/pharmacology , Lactams/pharmacology , Limonins/pharmacology , Drug Evaluation, Preclinical/methods , Glycoside Hydrolase Inhibitors/chemistry , Glycoside Hydrolase Inhibitors/isolation & purification , Inhibitory Concentration 50 , Lactams/chemistry , Lactams/isolation & purification , Limonins/chemistry , Limonins/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Leaves/chemistry , Plants, Medicinal/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...