ABSTRACT
Herein, we described a tunable method for synthesis of novel hollow mesoporous carbon (MPC) via direct pyrolysis (800oC) of MIL-53 (Fe) as a self-sacrificed template. The structural characterization revealed a hollow, amorphous, defective and mesoporous MPC along with high surface area (approx. 200 m2 g-1). For the experiments of ibuprofen adsorption onto MPC, effects of contact time, MPC dosage, ionic strength, concentration and temperature were systematically investigated. The optimal conditions consisted of pH = 3, concentration 10 mg l-1 and dose of 0.1 g l-1 for the highest ibuprofen removal efficiency up to 88.3% after 4 h. Moreover, adsorption behaviour, whereby chemisorption and monolayer controlled the uptake of ibuprofen over MPC, were assumed. Adsorption mechanisms including H-bonding, π-π interaction, metal-oxygen, electrostatic attraction were rigorously proposed. In comparison to several studies, the MPC nanocomposite in this work obtained the outstanding maximum adsorption capacity (206.5 mg g-1) and good reusability (5 cycles); thus, it can be used as a feasible alternative for decontamination of ibuprofen anti-inflammatory drug from water.
ABSTRACT
An aerobic coupling of 2-aminopyrimidines or 2-aminopyridines with trans-chalcones to afford aroylimidazo[1,2-a]pyrimidines and aroylimidazo[1,2-a]pyridines is reported. Reactions proceed in the presence of CuFe2O4 superparamagnetic nanoparticle catalyst, two equivalents of iodine, oxygen oxidant, and 1,4-dioxane solvent. The catalyst is superior to many common copper or iron complexes. Copper ferrite could be easily separated by magnetic decantation and reused up to 5 times without a major loss of activity. The method described here marks a rare example of using a simple, heterogeneous catalyst for synthesis of fused heterocycles. To our best knowledge, aroylimidazo[1,2-a]pyrimidines and aroylimidazo[1,2-a]pyridines were not previously synthesized using this protocol.
ABSTRACT
Nosocomially-acquired salmonellosis is uncommonly reported in Australia. We report a cluster of gastroenteritis caused by Salmonella Typhimurium phage type 170 (STm 170) centred on a tertiary paediatric hospital in Sydney, New South Wales from 8 to 19 May 2004. A total of 12 children had STm 170 isolated from faecal specimens. Of the 12 cases, seven were acquired in hospital and five in the community. The mean age of the cases was 4.1 years (range: 2 months to 11.2 years). We conducted a case series investigation to generate hypotheses regarding the cause of this outbreak. Standardised interviews with cases' parents were conducted to identify potential exposures including in recently consumed food. An environmental investigation mapped the food preparation and storage areas, movements of staff caring for cases, relative case-bed locations, and duration of stay in these locations. Five of the seven hospital-acquired cases were immunocompromised with a history of prolonged and/or multiple hospital admissions. We found that STm 170 was probably brought into the hospital by a community-acquired case and spread to other in-patients through person-to-person transmission by hospital staff and/or patients. This study emphasises the importance of stringent compliance with hospital infection control practices at all times.
