Development of Vang Danh anthracite as a cost-effective anode for sodium-ion batteries through a heat-treatment process.

This study focuses on the effects of the chemical process and heating time at 900 °C on pristine anthracite coal (provided by Vang Danh coal, Quang Ninh province, Vietnam) and explores its structure and electrochemical performance when used as an anode in Na-ion batteries. After chemical treatment with NaOH and H2SO4, the impurity content in the raw material decreased significantly (e.g., ash content dropped from 4.4% to 0.9%, etc.). The interspacing between the graphene layers in the anthracite structure also increased after the heat treatment. Besides, on extending the heating time, the anthracite structure became more disordered than the samples heated for shorter times. Therefore, the intercalation ability of Na+ ions in the anthracite structure increased, and the sample heated at 900 °C for 6 hours exhibited the highest reversible capacity of up to 160 mA h g-1 with adequate capacity retention after 100 cycles at C/10 rate.

Bioglue endovascular treatment of fusiform aneurysm rupture of the distal anterior temporal artery of the middle cerebral artery: a case report.

The treatment of a ruptured fusiform distal anterior temporal artery aneurysm is a challenge for the stroke physician, however surgical closure and coil endovascular intervention are options. A total blockage can result in memory problems as well as object-related questions. We'd like to provide the clinical example of a 56-year-old woman with many underlying medical illnesses who was admitted to the hospital with a grade 7/10 headache and a Glasgow score of 15, but no focal neurological deficits, and was diagnosed with a ruptured distal temporal artery aneurysm. The aneurysm is positioned in the distal region, making endovascular intervention difficult to perform. As a result, we used an endovascular approach to repair with bioglue. When a patient develops fusiform aneurysms of the distal temporal artery, our findings provide an additional therapy option.

Vegans and vegetarians living in Nottingham (UK) continue to be at risk of iodine deficiency.

Iodine is essential for thyroid hormone synthesis. Individuals adhering to vegan and vegetarian diets have been found to be vulnerable to iodine deficiency. Yet, iodine has not been monitored in these groups across time. This study aims to investigate iodine status, intake and knowledge in vegans, vegetarians and omnivores and determine changes between 2016-2017 and 2019. Dietary intake (µg/d) was estimated by 3-d food diaries and iodine FFQ. Urinary iodine concentration, analysed by inductively coupled plasma mass spectrometry, assessed iodine status according to WHO criteria. Iodine knowledge was scored by an adapted questionnaire. IBM SPSS was used for statistical analysis. Ninety-six adults (18-60 years) were recruited in October 2016-2017 (vegans: 12; vegetarians: 5; omnivores: 43) and June 2019 (vegans: 7; vegetarians: 10;omnivores: 19). Median dietary iodine was below the Reference Nutrient Intake for all groups. Vegans and vegetarians had the lowest iodine intake. Vegans had significantly lower iodine intake than omnivores (2016-2017, P = 0 032; 2019, P = 0 001). Omnivores had the highest iodine status (2016-2017, 79 4 µg/l; 2019, 72 4 µg/l) and vegans the lowest (2016-2017, 31 2 µg/l; 2019, 12 2 µg/l). Iodine knowledge was poor but did not differ between dietary groups (2016-2017, P = 0 219; 2019, P = 0 532). Vegans and vegetarians continue to be at risk of iodine deficiency. Further, iodine intake in the UK is poor independent of dietary choice. Iodine education is needed along with research into improving iodine nutrition at national level.

Neural side effect discovery from user credibility and experience-assessed online health discussions.

BACKGROUND: Health 2.0 allows patients and caregivers to conveniently seek medical information and advice via e-portals and online discussion forums, especially regarding potential drug side effects. Although online health communities are helpful platforms for obtaining non-professional opinions, they pose risks in communicating unreliable and insufficient information in terms of quality and quantity. Existing methods in extracting user-reported adverse drug reactions (ADRs) in online health forums are not only insufficiently accurate as they disregard user credibility and drug experience, but are also expensive as they rely on supervised ground truth annotation of individual statement. We propose a NEural ArchiTecture for Drug side effect prediction (NEAT), which is optimized on the task of drug side effect discovery based on a complete discussion while being attentive to user credibility and experience, thus, addressing the mentioned shortcomings. We train our neural model in a self-supervised fashion using ground truth drug side effects from mayoclinic.org. NEAT learns to assign each user a score that is descriptive of their credibility and highlights the critical textual segments of their post. RESULTS: Experiments show that NEAT improves drug side effect discovery from online health discussion by 3.04% from user-credibility agnostic baselines, and by 9.94% from non-neural baselines in term of F1. Additionally, the latent credibility scores learned by the model correlate well with trustworthiness signals, such as the number of "thanks" received by other forum members, and improve credibility heuristics such as number of posts by 0.113 in term of Spearman's rank correlation coefficient. Experience-based self-supervised attention highlights critical phrases such as mentioned side effects, and enhances fully supervised ADR extraction models based on sequence labelling by 5.502% in terms of precision. CONCLUSIONS: NEAT considers both user credibility and experience in online health forums, making feasible a self-supervised approach to side effect prediction for mentioned drugs. The derived user credibility and attention mechanism are transferable and improve downstream ADR extraction models. Our approach enhances automatic drug side effect discovery and fosters research in several domains including pharmacovigilance and clinical studies.

Quantum cascade lasers grown on silicon.

Technological platforms offering efficient integration of III-V semiconductor lasers with silicon electronics are eagerly awaited by industry. The availability of optoelectronic circuits combining III-V light sources with Si-based photonic and electronic components in a single chip will enable, in particular, the development of ultra-compact spectroscopic systems for mass scale applications. The first circuits of such type were fabricated using heterogeneous integration of semiconductor lasers by bonding the III-V chips onto silicon substrates. Direct epitaxial growth of interband III-V laser diodes on silicon substrates has also been reported, whereas intersubband emitters grown on Si have not yet been demonstrated. We report the first quantum cascade lasers (QCLs) directly grown on a silicon substrate. These InAs/AlSb QCLs grown on Si exhibit high performances, comparable with those of the devices fabricated on their native InAs substrate. The lasers emit near 11 µm, the longest emission wavelength of any laser integrated on Si. Given the wavelength range reachable with InAs/AlSb QCLs, these results open the way to the development of a wide variety of integrated sensors.

Vivax malaria: preliminary observations following a shorter course of treatment with artesunate plus primaquine.

The standard adult treatment regimen for Plasmodium vivax malaria is chloroquine (1500 mg over 3 d) plus primaquine (15 or 30 mg daily for 14 d), but patient compliance tends to be poor with the lengthy course. Preliminary observations are reported on the efficacy of a shorter treatment course - artesunate (200mg twice a day for 2 d) plus primaquine (22.5mg base twice a day for 7 d) - given to 28 adult patients infected with P. vivax in Viet Nam. All patients responded quickly to treatment with mean (SD) parasite and fever clearance times of 14.2 (4.0) and 18.6 (8.4) h, respectively. The high dose of primaquine was generally well tolerated, and only one patient (3.6%) had a recurrence of parasitaemia during 28 d of follow-up. As most patients infected with Southeast Asian strains of P. vivax have their first relapse within 28 d after treatment with rapidly eliminated blood schizonticides, the absence of parasitaemia in the remaining 27 patients suggests that this drug regimen was active against both blood and liver stages. Further studies are needed to confirm that this rapidly acting, short artesunate-primaquine regimen can result in better patient compliance and treatment outcomes than the chloroquine-primaquine regimen.

Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria.

Food has been reported to increase the bioavailability of mefloquine in healthy volunteers, but its role in increasing blood mefloquine concentrations in malaria patients treated with mefloquine is unclear. In this study, we compared blood mefloquine concentrations after the administration of artesunate (8 mg/kg) and mefloquine (15 mg/kg) over 12h with either a low-fat (approximately 3g of fat) or high-fat (approximately 30 g of fat) meal for the treatment of Plasmodium falciparum malaria in 12 Vietnamese patients. No statistical differences were detected in the following kinetic parameters between the low-fat (n=6) and high-fat (n=6) groups, respectively: maximum blood mefloquine concentrations (2838+/-531 ng/ml and 2556+/-657 ng/ml, 95% CI -486 to 1050 ng/ml, P=0.43) and the area under the blood mefloquine concentration versus time curves (246.8+/-58.3 microg.h/ml and 238.3+/-28.4 microg.h/ml, 95% CI -50.5 to 67.5 microg.h/ml, P=0.75). A fatty meal does not appear to increase the bioavailability of mefloquine in malaria patients and should not affect the response of malaria infections to treatment.

The variation of ultrasonic image of acute inflamation of gall bladder (AIGB) due to bile stone in gall bladder and bile stone in gall bladder combining with bile stone in major bile duct (MBD)

At Hospital No175 from 1998 to 2001, the study was conducted on 152 subjects (78 female, 74 male), no statistically significant difference of age, divided into various groups: group of due to stone (40 subjects), group of AIGB combining with stenosis of MBD (42 subjects). Two control group comprise of IGB due to stone (36 subjects), group of stenosis of MBD due to stone (34 subjects). In AIGB the dimention of gall bladder (+B) was not enlarged. The variation of this dimention relates to the severity of stenosis of MBD or the shrinkage of the GB. Murphy sign varies according to the severity of stenosis. The signs in internal wall of GB is the main symptoms reflecting the variation of the wall and the condition in GB. Acute damage of the wall of GB does not change sigificantly the ultrasonic sign of chronic inflammation in the wall of GB. For strenthening the accurary of the diagnosis it must not any sign note solitarily but it has to combine 2-3 signs