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Bioorg Med Chem Lett
; 25(18): 3836-9, 2015 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-26235947
ABSTRACT
The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the indazole series displayed in vivo activity in reducing the enzymatic activity of liver delta-5 desaturase.