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1.
J Dev Orig Health Dis ; 8(6): 638-648, 2017 Dec.
Article in English | MEDLINE | ID: mdl-28651674

ABSTRACT

Prenatal stress and prenatal nutrition each have demonstrable impact on fetal development, with implications for child neurodevelopment and behavior. However, few studies have examined their joint influences despite evidence of potential interactive effects. We examined associations among prenatal stress, prenatal antioxidant intakes, and child temperament in a sociodemographically diverse pregnancy cohort (N=137 mother-child dyads). In mid-pregnancy, mothers completed an assessment of recent negative life events as a measure of prenatal stress and an assessment of prenatal diet. When the children were 30 months of age, mothers completed the Early Childhood Behavior Questionnaire-Very Short form, which provides scores on child Negative Affectivity, Effortful Control, and Surgency/Extraversion. Linear regressions tested associations between maternal prenatal negative life events and child temperament, and effect modification by maternal prenatal antioxidant intakes (vitamins A, C, and E, magnesium, zinc, selenium, ß-carotene). Analyses revealed that increased maternal prenatal negative life events were associated with higher child Negative Affectivity (ß=0.08, P=0.009) but not with child Effortful Control (ß=-0.03, P=0.39) or Surgency/Extraversion (ß=0.04, P=0.14). Prenatal intakes of zinc and selenium modified this effect: Maternal exposure to prenatal negative life events was associated with higher child Negative Affectivity in the presence of lower intakes of zinc and selenium. Modification effects approached significance for vitamins A and C. The results suggest that the combination of elevated stress exposures and lower antioxidant intakes in pregnancy increases the likelihood of heightened child temperamental negative affectivity. Increased antioxidant intakes during pregnancy may protect against influences of prenatal stress on child temperament.


Subject(s)
Antioxidants/administration & dosage , Child Development , Maternal Exposure/adverse effects , Mothers/psychology , Pregnancy Complications/psychology , Prenatal Exposure Delayed Effects/epidemiology , Temperament , Adult , Child, Preschool , Female , Humans , Male , Pregnancy , Pregnancy Complications/epidemiology , Pregnancy Complications/etiology , Prenatal Nutritional Physiological Phenomena
2.
Thorac Cardiovasc Surg ; 58(6): 374-6, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20824598

ABSTRACT

Isolated congenital left ventricular diverticulum is a rare malformation and fewer than 50 cases have been reported to date. We report here on a patient with the symptoms of atypical chest pain and distress, who had a successful surgical intervention for this malformation.


Subject(s)
Diverticulum/congenital , Heart Defects, Congenital/complications , Heart Ventricles/abnormalities , Cardiac Surgical Procedures , Chest Pain/etiology , Diverticulum/diagnostic imaging , Diverticulum/surgery , Female , Heart Defects, Congenital/diagnostic imaging , Heart Defects, Congenital/surgery , Heart Ventricles/diagnostic imaging , Heart Ventricles/surgery , Humans , Middle Aged , Treatment Outcome , Ultrasonography
4.
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