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1.
J Nucl Med Technol ; 45(3): 193-197, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28705927

ABSTRACT

The brain is the most common site of distant metastasis from lung cancer. Thus, MRI of the brain at initial staging is routinely performed, but if this examination is negative a follow-up examination is often not performed. This study evaluates the incidence of asymptomatic brain metastases in non-small cell lung cancer patients detected on follow-up 18F-FDG PET/CT scans. Methods: In this Institutional Review Board-approved retrospective review, all vertex to thigh 18F-FDG PET/CT scans in patients with all subtypes of lung cancer from August 2014 to August 2016 were reviewed. A total of 1,175 18F-FDG PET/CT examinations in 363 patients were reviewed. Exclusion criteria included brain metastases on initial staging, histologic subtype of small-cell lung cancer, and no follow-up 18F-FDG PET/CT examinations. After our exclusion criteria were applied, a total of 809 follow-up 18F-FDG PET/CT scans in 227 patients were included in the final analysis. The original report of each 18F-FDG PET/CT study was reviewed for the finding of brain metastasis. The finding of a new brain metastasis prompted a brain MRI, which was reviewed to determine the accuracy of the 18F-FDG PET/CT. Results: Five of 227 patients with 809 follow-up 18F-FDG PET/CT scans reviewed were found to have incidental brain metastases. The mean age of the patients with incidental brain metastasis was 68 y (range, 60-77 y). The mean time from initial diagnosis to time of detection of incidental brain metastasis was 36 mo (range, 15-66 mo). When MRI was used as the gold standard, our false-positive rate was zero. Conclusion: By including the entire head during follow-up 18F-FDG PET/CT scans of patients with non-small cell lung cancer, brain metastases can be detected earlier while still asymptomatic. But, given the additional scan time, radiation, and low incidence of new brain metastases in asymptomatic patients, the cost-to-benefit ratio should be weighed by each institution.


Subject(s)
Brain Neoplasms/epidemiology , Brain Neoplasms/secondary , Carcinoma, Non-Small-Cell Lung/diagnostic imaging , Carcinoma, Non-Small-Cell Lung/epidemiology , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/epidemiology , Positron Emission Tomography Computed Tomography/statistics & numerical data , Aged , Aged, 80 and over , Arizona/epidemiology , Brain Neoplasms/diagnostic imaging , Comorbidity , Female , Fluorodeoxyglucose F18 , Humans , Incidence , Male , Middle Aged , Positron Emission Tomography Computed Tomography/methods , Radiopharmaceuticals , Reproducibility of Results , Risk Factors , Sensitivity and Specificity
2.
Clin Nucl Med ; 42(9): e422-e423, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28682846

ABSTRACT

A 41-year-old man with gastric adenocarcinoma presented with hepatic metastases. The metastases were refractory to systemic chemotherapy, so radioembolization with Y microspheres was performed. Because of stasis or saturation of the tumor with embolic particles, 79% of the microspheres were injected. At follow-up, the patient complained of "red bumps" that had developed on his right foot/ankle the day after the radioembolization. Because a portion of the dose was still in the catheter when withdrawn from the right femoral artery, the interventional radiologist used a Geiger counter to confirm radioactivity in the cutaneous lesions and thus the distal embolization of the microspheres.


Subject(s)
Ankle/radiation effects , Dermatitis/etiology , Embolization, Therapeutic/adverse effects , Foot/radiation effects , Microspheres , Radiation Injuries/etiology , Yttrium Radioisotopes/adverse effects , Adenocarcinoma/pathology , Adult , Humans , Liver Neoplasms/radiotherapy , Liver Neoplasms/secondary , Male , Radiometry , Stomach Neoplasms/pathology , Yttrium Radioisotopes/therapeutic use
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