Hemorrhagic Fever with Renal Syndrome Complicated by Acute Pancreatitis, High Intraocular Pressure, and Pulmonary Involvement: a Case Report.

Hemorrhagic fever with renal syndrome (HFRS), a naturally occurring epidemic disease, is primarily caused by hantaviruses. It frequently involves the lungs and is characterized by symptoms such as fever, hemorrhage, and renal failure. However, the occurrence of acute pancreatitis (AP) in HFRS patients can be neglected, and high intraocular pressure (IOP) is exceedingly uncommon. In this report, we discuss the case of a 30-year-old male who presented with fever, nausea, vomiting, and abdominal pain. Physical examination revealed extremity petechiae rashes and elevated IOP. Laboratory tests indicated coagulopathy and renal failure. A computed tomography scan confirmed AP. Further testing revealed a positive anti-hantavirus IgM antibody. The patient received supportive care, fluid hydration, hemofiltration, mannitol, brinzolamide, and brimonidine to reduce IOP. Three days post-admission, the patient developed shortness of breath and chest pain. Subsequent chest computed tomography revealed pulmonary edema and bilateral pleural effusion. Treatment included oxygen supply, respiratory support, and thoracentesis, with continued hemofiltration. The patient recovered, regaining normal pulmonary and renal functions and normalized IOP. This case underscores the importance of comprehensive evaluations and vigilant monitoring in HFRS patients, particularly measuring IOP in those with visual complaints, to save lives and reduce morbidity.

Molecular dynamics revealed the effect of epoxy group on triglyceride digestion.

The digestion behavior of epoxy triglyceride, the main cytotoxic product of deep-frying oil, remains unknown, which may affect its biosafety. In this study, epoxy triglyceride (EGT) and triglyceride (GT) were used to reveal the effect of epoxy group on digestion. Digestibility rate analysis showed that the free fatty acids release rate of EGT was slower. To clarify this phenomenon, binding ability with salt ions in digestive juice and particle size were also been studied. Cluster size analysis indicated that epoxy group increased triglyceride particle size, resulting in smaller contact area between EGT and lipase. Interface behaviors displayed EGT decreased binding ability with salt ions in digestive juice. Spectroscopic analysis showed EGT caused the red shift of lipase peak, indicating that epoxy group changed lipase structure. Molecular dynamics simulation suggested EGT leads to loosen lipase structure. In conclusion, this study highlights that epoxy group could weaken the triglyceride digestion.

Deep-frying oil induces cytotoxicity, inflammation and apoptosis on intestinal epithelial cells.

BACKGROUND: Deep-frying oil has been found to cause inflammatory bowel disease (IBD). However, the molecular mechanism of the effect of deep-frying palm oil on IBD still remains undetermined. RESULTS: In the present study, bioinformatics and cell biology were used to investigate the functions and signal pathway enrichments of differentially expressed genes. The bioinformatics analysis of three original microarray datasets (GSE73661, GSE75214 and GSE126124) in the NCBI-Gene Expression Omnibus database showed 17 down-regulated genes (logFC < 0) and 2 up-regulated genes (logFC > 0) existed in the enteritis tissue. Meanwhile, pathway enrichment and protein-protein interaction network analysis suggested that IBD is relevant to cytotoxicity, inflammation and apoptosis. Furthermore, Caco-2 cells were treated with the main oxidation products of deep-frying oil-total polar compounds (TPC) and its components (polymerized triglyceride, oxidized triglycerides and triglyceride degradation products) isolated from deep-frying oil. The flow cytometry experiment revealed that TPC and its components could induce apoptosis, especially for oxidized triglyceride. A quantitative polymerase chain reaction analysis demonstrated that TPC and its component could induce Caco-2 cell apoptosis through AQP8/CXCL1/TNIP3/IL-1. CONCLUSION: The present study provides fundamental knowledge for understanding the effects of deep-frying oils on the cytotoxic and inflammatory of Caco-2 cells, in addition to clarifying the molecular function mechanism of deep-frying oil in IBD. © 2021 Society of Chemical Industry.

[Post-marketing clinical safety assessment of Shenmai injection based on active monitoring and passive monitoring in large data background].

This paper adopted a series of related analysis methods to comprehensively analyze post-marketing clinical safety data of Shenmai injection from 4,220 cases of SRS and 32,358 cases of multicenter, prospective, registered hospital centralized monitoring in large data background, calculated ADR incidence rate was 0.93 per 1,000, main symptoms of ADR includes chest pain, chills, skin itching, palpitations, fever, nausea, dizziness, vomiting, flushing, numbness, allergic reaction, cyanosis, rash, low back pain, and "breath", "anaphylactoid reaction" and "flush" were the safety warning signals of Shenmai injection. Primary disease for chronic pulmonary heart disease, thyroid disease, and combined with cerebral vascular disease, prior to the injection and continuous use of alprostadil, cyclic adenosine monophosphate, combined with quinolones, penicillins were suspicious influence factors of ADR of Shenmai injection, these promot the clinical safety.

Post-marketing clinical safety assessment of Shenmai injection based on active monitoring and passive monitoring in large data background / 中国中药杂志

This paper adopted a series of related analysis methods to comprehensively analyze post-marketing clinical safety data of Shenmai injection from 4,220 cases of SRS and 32,358 cases of multicenter, prospective, registered hospital centralized monitoring in large data background, calculated ADR incidence rate was 0.93 per 1,000, main symptoms of ADR includes chest pain, chills, skin itching, palpitations, fever, nausea, dizziness, vomiting, flushing, numbness, allergic reaction, cyanosis, rash, low back pain, and "breath", "anaphylactoid reaction" and "flush" were the safety warning signals of Shenmai injection. Primary disease for chronic pulmonary heart disease, thyroid disease, and combined with cerebral vascular disease, prior to the injection and continuous use of alprostadil, cyclic adenosine monophosphate, combined with quinolones, penicillins were suspicious influence factors of ADR of Shenmai injection, these promot the clinical safety.

[Characteristics of particle size structure of plankton community in turbidity zone of near-shore waters, Liaoning Province of Northeast China].

Estuary and nearshore waters have complicated environment, where plankton community has a frequent feedback regulation and a very unstable particle size structure. In this paper, an investigation was made on the particle size structure of plankton in the turbidity zone of nearshore and port area waters in Liaoning Province of Northeast China. In the waters with high concentration inorganic nitrogen, phytoplankton biomass was mainly of small particle sizes, with the equivalent sphere diameter (ESD) being primarily 20-100 micro m, while in low nutrient waters, the phytoplankton biomass was mainly of larger size particles, with the ESD>100 micro m, indicating that the phytoplankton feedback regulation caused the phytoplankton community to be comprised of small sized organisms as part of the biological responses to high concentration suspended solids, which reduced the individual number of larger organisms such as Coscinodiscus. sp. and other species, and in turn, directly affected the fisheries resources, including a variety of fish and shrimp larvae fed on phytoplankton. A normalized biomass size spectrum with the characteristics of nearshore shallow aquatic oceanic ecosystems exhibiting eutrophication was constructed. The spectrum slope indicated that the plankton community biomass would gradually increase in size. The feasibility of using dinoflagellates and cladocerans as the bio-indicators for eutrophication was discussed.

Mechanism of glutamate receptor for excitation of medial vestibular nucleus induced by acute hypotension.

In the vestibular nuclei, acute hypotension induces excitation of electrical activity and expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK). Expression of c-Fos protein and pERK is mediated by the excitatory neurotransmitter, glutamate. We investigated the signaling pathway of glutamate and its receptors in the vestibular nuclei following acute hypotension in conscious rats. Glutamate release and the expression of c-Fos protein in the medial vestibular nuclei (MVN) were measured by microdialysis and immunohistochemical analysis, respectively. We compared the responses of rats with unilateral labyrinthectomy to unaltered controls. Acute hypotension was induced by infusing sodium nitroprusside (SNP) into the femoral vein. In the control group, glutamate release and the expression of c-Fos protein increased in the bilateral MVN following acute hypotension. In the unilateral labyrinthectomy group, glutamate release and the expression of c-Fos protein increased in the MVN contralateral to the lesion, but did not change in the ipsilateral MVN following acute hypotension. Microinjection of NMDA or AMPA into the lateral ventricle increased the expression of c-Fos protein in the bilateral MVN of conscious intact labyrinthine rats. However, after intracerebroventricular microinjection of MK-801 or CNQX little c-Fos protein was expressed in the bilateral MVN of these rats following acute hypotension. These results suggest that in response to acute hypotension, excitatory afferent signals from the peripheral vestibular receptors release glutamate into postsynaptic neurons in the vestibular nuclei. These excitatory signals are transmitted through the NMDA receptors and AMPA receptors of glutamate in the vestibular system.

Three new dammarane-type triterpene saponins from the leaves of Panax ginseng C.A. Meyer.

Three new dammarane-type triterpene ginsenosides, together with six known ginsenosides, were isolated from the leaves of Panax ginseng C.A. Meyer. The new saponins were named as ginsenoside Rh11, ginsenoside Rh12, and ginsenoside Rh13. Their structures were elucidated as (20S)-3ß,6α,12ß,20-tetrahydroxydammara-25-ene-24-one 20-O-ß-d-glucopyranoside (1), (20S)-3ß,12ß,20,24,25-pentahydroxydammarane 20-O-ß-d-glucopyranoside (2), and (20S,23E)-3ß,12ß,20,25-tetrahydroxydammara-23-ene 20-O-ß-d-glucopyranoside (3) on the basis of 1D and 2D NMR experiments and mass spectra. The known ginsenosides were identified as ginsenoside M(7cd), ginsenoside Rg6, ginsenoside Rb3, gypenoside XVII, gypenoside IX, and 20-(E)-ginsenoside F4.

[Effects of expansion fashion and expansion quantity on retention of cement-expanded composite screw post].

OBJECTIVE: To study the effects of expansion fashion and expansion quantity on retention of cement-expanded composition screw post (CECSP). METHODS: Ninety simulated tooth roots made of polymethylmethacrylate were divided into ten groups, each fashion induded five groups. The expanded plastic sheath of tricuspid valve was made with the special separated valve device and cemented and tightened up into root with the screw post at the same time by ZPC. Then the root and screw post-core system was tested by the speed of 10 mm/min on the INSTRON 4302 and the retention force was recorded. RESULTS: It appeared that the difference between different expansion fashion and different expansion quantity were significantly (P < 0.05). The retention of expansion fashion one was significantly greater than those of fashion two. The retention was best when expansion quantity was within 10%. CONCLUSION: During clinic operation, we should apply definite fashion and control the expansion quantity within 10%, and the screw post should tighten up to the bottom of prepared root.

[Fracture resistence force of the cement-expanded composite screw post-core system].

OBJECTIVE: This is a study comparing the effects of different post designs on the fracture resistence. METHODS: Twenty-seven simulated tooth roots made of polymethyl methacrylate (PMMA) were divided into three groups, then the cement-expanded composite screw post-core system (CECSP), cement screw post-core system (CSP) and cast metal post-core system (CMP) were manufactured. The root and post-core system was compressed by the speed of 1 mm/min on the Instron 4302 and the fracture resistence force was recorded. RESULTS: Statistical analysis of the measured values showed the fracture resistence force of CECSP and CMP to be significantly greater than that of CSP (P < 0.05), but there was no significant difference between the fracture resistence force of CECSP and CMP (P > 0.05). CONCLUSION: The fracture mechanical properties of CECSP are much better than those of cement screw post-core system and are similar to cast metal post-core system. Therefore, it is possible to find a new way for restoration of endodontally treated teeth.

Effects of expansion fashion and expansion quantity on retention of cement-expanded composite screw post / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To study the effects of expansion fashion and expansion quantity on retention of cement-expanded composition screw post (CECSP).</p><p><b>METHODS</b>Ninety simulated tooth roots made of polymethylmethacrylate were divided into ten groups, each fashion induded five groups. The expanded plastic sheath of tricuspid valve was made with the special separated valve device and cemented and tightened up into root with the screw post at the same time by ZPC. Then the root and screw post-core system was tested by the speed of 10 mm/min on the INSTRON 4302 and the retention force was recorded.</p><p><b>RESULTS</b>It appeared that the difference between different expansion fashion and different expansion quantity were significantly (P < 0.05). The retention of expansion fashion one was significantly greater than those of fashion two. The retention was best when expansion quantity was within 10%.</p><p><b>CONCLUSION</b>During clinic operation, we should apply definite fashion and control the expansion quantity within 10%, and the screw post should tighten up to the bottom of prepared root.</p>