Erratum: Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study.

This corrects the article DOI: 10.1038/srep20010.

Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study.

Congenital pseudarthrosis of the tibia (CPT) is a rare disease which normally presents itself during early childhood by anterolateral bowing of the tibia and spontaneous tibial fractures. Although the exact etiology of CPT is highly debated, 40-80% of CPT patients are carriers of a mutation in the Neurofibromatosis Type 1 (NF1) gene, which can potentially result in an altered phenotype of the skeletal cells and impaired bone healing. In this study we use a computational model of bone regeneration to examine the effect of the Nf1 mutation on bone fracture healing by altering the parameter values of eight key factors which describe the aberrant cellular behaviour of Nf1 haploinsufficient and Nf1 bi-allelically inactivated cells. We show that the computational model is able to predict the formation of a hamartoma as well as a wide variety of CPT phenotypes through different combinations of altered parameter values. A sensitivity analysis by "Design of Experiments" identified the impaired endochondral ossification process and increased infiltration of fibroblastic cells as key contributors to the degree of severity of CPT. Hence, the computational model results have added credibility to the experimental hypothesis of a genetic cause (i.e. Nf1 mutation) for CPT.

A measurement system for an automatic survey of low frequency magnetic and electric fields.

In this paper we propose and verify by experiment a measurement system capable to survey both magnetic (H) and electric (E) fields at the same point, considering that the existing low frequency (50 Hz-10 kHz) instruments permit the survey at two different points, one for H and the other for E. This measurement system has a sensor with a special configuration, with a sensitivity to electric field of 1.3 mV∕(V∕m), and a sensitivity to magnetic induction of 143 mV∕µT. The instrument is suitable for long term survey of low frequency H and E fields by making spot measurements of the fields, both time domain and frequency domain representations of H and E. The correlation between the theoretical analysis of the instrument and the experimental results was very good. The proposed measurement system was used for an automatic survey of background magnetic and electric fields generated by power line in a room from an apartment building. These results are presented in this paper, highlighting the performances of the instrument.

Omni-directional selective shielding material based on amorphous glass coated microwires.

The shielding effectiveness of the omni-directional selective shielding material based on CoFe-glass coated amorphous wires in 0.8 GHz-3 GHz microwave frequency range is investigated. The measurements were done in a controlled medium using a TEM cell and in the free space using horn antennas, respectively. Experimental results indicate that the composite shielding material can be developed with desired shielding effectiveness and selective absorption of the microwave frequency range by controlling the number of the layers and the length of microwires.

[Importance of apical instrumentation limit in the endodontic technique]. / Importanta limitei apicale a instrumentatiei in tehnica endodontica.

An improved knowledge of anatomy and psysiology of the apical radicular region has made mandatory a better classical endodontic technique concerning the apical limit of instrumentation, and has stressed the importance of a precise determination of the cemento-dentinal junction as the apical limit of canal obturation. On the basis of these orientations a clinical and radiographic study was carried out on 120 teeth extracted form humans, in which the frequency was determined of the excentric position of the cement conus with regard to the apex, and the distance between the cemento-dentinal junction and the apex. In 45 teeth in situ, with pulpar inflammation, gangrene and apical parodontitis a clinical and radiological appraisal was done of the cemento-dentinal junction, and evolution was followed after canal obturation.

[Treatment of chronic marginal parodontopathy]. / Experienta noastra în tratamientul parodontitelor cronice marginale.

Complex parodontal therapy is the main object of interest in the field of specialized assistance provided by our group. Between 1971 and 1987 complex parodontal therapy was applied in a total of 616 patients, of which 150 between 1971 and 1975, 174 between 1976 and 1980, and 292 between 1981 and 1987. Therapy consisted in individualized procedures depending on general and local conditions, and was aimed at the control of the bacterial plaque, extraction of irrecuperable teeth, removal of the dental pulp when significant polishing had to be carried out for alignment in the occluding plane, and of prosthetic parallelism in pluriradicular teeth with involvement of the furcation (II-nd and III-rd degree) where radicular amputation was necessary, hemi- or bisection. Conservative therapy was completed by surgery with a view to suppress parodontal pouches, and by functional therapy with a view to achieve morphological and functional balance of the dental arcs, with high priority to the conjuncted type. In all the cases maintenance therapy was applied, with periodical controls performed at least twice a year with a view to obtain an effective control of the bacterial plaque, and for removal of dental deposits.