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1.
The immediate vicinity of mouse metallothionein-I gene contains two sites conferring glucocorticoid inducibility to the heterologous promoter.
Plisov, S Y; Nichiporenko, M G; Shkapenko, A L; Kumarev, V P; Baranova, L V; Merkulova, T I.
FEBS Lett ; 358(1): 104, 1995 Jan 16.
Article in English | MEDLINE | ID: mdl-7821419

Subject(s)
Glucocorticoids/pharmacology , Metallothionein/genetics , Promoter Regions, Genetic/drug effects , Animals , Base Sequence , Consensus Sequence/genetics , Mice , Molecular Sequence Data
2.
The immediate vicinity of mouse metallothionein-I gene contains two sites conferring glucocorticoid inducibility to the heterologous promoter.
Plisov, S Y; Nichiporenko, M G; Shkapenko, A L; Kumarev, V P; Baranova, L V; Merkulova, T I.
FEBS Lett ; 352(3): 339-41, 1994 Oct 03.
Article in English | MEDLINE | ID: mdl-7925998

ABSTRACT

Glucocorticoid responsive elements (GREs) located -252 to -209 by upstream and +1011 to +1054 bp downstream of the transcription initiation site of the mouse metallothionein-I (mMT-I) gene were identified in transient experiments. However, the promoter region of the mMT-I gene (-330 to +70 bp) was found to provide low, if any, glucocorticoid induction of the linked CAT gene, while showing strong cadmium regulation, comparable with the in vivo level.


Subject(s)
Dexamethasone/pharmacology , Enhancer Elements, Genetic/drug effects , Glucocorticoids/pharmacology , Metallothionein/biosynthesis , Metallothionein/genetics , Promoter Regions, Genetic/drug effects , Animals , Base Sequence , Cadmium/pharmacology , Chloramphenicol O-Acetyltransferase/biosynthesis , Consensus Sequence , L Cells , Mice , Molecular Sequence Data , Plasmids , Transfection
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