ABSTRACT
In a randomised double-blind study, the effects on red cell deformability of a single sublingual dose of nifedipine were compared with placebo in eight patients with stable angina pectoris. Red cell deformability, measured by filtration and centrifugation techniques, was significantly increased at rest in all eight patients 1 h after nifedipine, while no change occurred after placebo. The improvement in deformability after nifedipine was maintained at the end of a period of exercise and unchanged from resting values after placebo. The results suggest that the increased deformability of red cells after nifedipine could contribute to the therapeutic effects of the drug in myocardial ischaemia.
Subject(s)
Angina Pectoris/drug therapy , Erythrocytes/drug effects , Nifedipine/therapeutic use , Aged , Blood Viscosity/drug effects , Double-Blind Method , Female , Hematocrit , Humans , Male , Middle Aged , Physical Exertion , Random AllocationSubject(s)
Pesticide Residues/analysis , Pesticides/analysis , Water Pollution, Chemical/analysis , Animals , Chromatography, Thin Layer , Costs and Cost Analysis , Fishes , Herbicides/analysis , Hydrocarbons, Chlorinated , Insecticides/analysis , Methods , Soil/analysis , Time Factors , United StatesSubject(s)
Hydrocarbons, Halogenated/standards , Insecticides/standards , Water Pollution/prevention & control , Water Supply , Animals , Brain/enzymology , Cholinesterase Inhibitors , Environmental Health , Fishes , Hydrocarbons, Halogenated/analysis , Insecticides/analysis , United States , Water/analysisABSTRACT
The suggested methods for evaluating water quality with respect to its content of selected groups of pesticides are based on interpretation of generally available information. They are intended to provide a base for discussion leading to the development of public policy for the inclusion of such values in water quality standards.
