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1.
J Allergy Clin Immunol ; 104(4 Pt 1): 763-8, 1999 Oct.
Article in English | MEDLINE | ID: mdl-10518819

ABSTRACT

BACKGROUND: Asthma mortality rates continue to be unacceptably high in the United States. As a follow-up to the initiatives proposed by the Asthma Mortality Task Force in 1987, the Committee on Asthma Mortality of the American Academy of Allergy, Asthma, and Immunology developed a questionnaire on fatal and near-fatal asthma. OBJECTIVE: This study assessed completeness of answers from participating physicians and described characteristics of patients with fatal and near-fatal asthma. METHODS: There were 111 survey items intended to characterize patients with fatal or near-fatal exacerbations of asthma. The questionnaire was sent to the members of the American Academy of Allergy, Asthma, and Immunology (approximately 3900), and a total of 143 usable questionnaires were received. RESULTS: Responding physicians had information on most items in the questionnaire; the mean number of responses was 120 of 143 possible, with a median of 128 and a range of 40 to 143. Patient demographics, description of the event, identification of overall risk for the event, use of medications, and characteristics of asthma management had the most complete responses (median response rates were 126-143). Presence of factors contributing to the event had fewer responses (range, 44-125). The physicians frequently had information on some psychologic characteristics (eg, 108 responses for depression and/or hopelessness and 127 responses for social support) but less information on several others (eg, 62 responses for family dysfunction). Statistical analysis of the completed surveys indicated that only 2 characteristics distinguished fatal from near-fatal asthma: progression in minutes (adjusted odds ratio, 4. 89; 95% confidence interval, 2.05-12.90) and absence of a past history of intubation (adjusted odds ratio, 3.55; 95% confidence interval, 1.55-8.97). CONCLUSIONS: There is a need to gather further data on patients with fatal and near-fatal events to design appropriate prospective studies on asthma morbidity and mortality rates. Physicians can contribute important information about these patients. Gathering such data would be enhanced by establishing a national registry on fatal and near-fatal asthma.


Subject(s)
Asthma/mortality , Population Surveillance/methods , Registries , Surveys and Questionnaires , Anti-Allergic Agents/therapeutic use , Asthma/drug therapy , Demography , Female , Humans , Male , Risk Factors , United States
3.
Ann Allergy Asthma Immunol ; 81(5): 415-20, 1998 Nov.
Article in English | MEDLINE | ID: mdl-9860033

ABSTRACT

This algorithm on the diagnosis and treatment of asthma is intended to complement and update the previously published Practice Parameters for the Diagnosis and Treatment of Asthma. Both documents were developed by the Joint Task Force on Practice Parameters, representing the AAAAI, ACAAI, and the JCAAI. The authors of this asthma algorithm have attempted to include all the elements essential for the diagnosis and care of patients with asthma. Every effort was made to keep the algorithm clear and concise, yet thorough and complete (Fig 1). Each component of the algorithm is elaborated further in a brief annotation. For further discussion, the reader is referred to the more extensive Practice Parameters for the Diagnosis and Treatment of Asthma.


Subject(s)
Asthma/diagnosis , Asthma/therapy , Acute Disease , Algorithms , Humans
6.
Curr Opin Pulm Med ; 3(1): 51-5, 1997 Jan.
Article in English | MEDLINE | ID: mdl-9139772

ABSTRACT

Excellent guidelines on the management of asthma are now available. The most comprehensive guidelines developed recently are the National Heart, Lung, and Blood Institute (NHLBI) Guidelines for the Diagnosis and Management of Asthma, the NHLBI/World Health Organization Global Initiative for Asthma, and the American Academy of Allergy, Asthma and Immunology and American College of Allergy, Asthma and Immunology Practice Parameters for the Diagnosis and Treatment of Asthma. The main purpose of such guidelines is to improve the quality of care for patients with asthma. This can only be accomplished, however, if these documents are used effectively.


Subject(s)
Asthma/diagnosis , Asthma/therapy , Practice Guidelines as Topic/standards , Education, Medical, Continuing , Global Health , Humans , Managed Care Programs , National Institutes of Health (U.S.) , Patient Education as Topic , Physician-Patient Relations , Pulmonary Medicine , Severity of Illness Index , United States
11.
J Allergy Clin Immunol ; 85(5): 959-64, 1990 May.
Article in English | MEDLINE | ID: mdl-1970585

ABSTRACT

Adverse reaction reports for inhaled relatively beta 2-selective, adrenergic-agonist bronchodilators submitted to the Center for Drug Evaluation and Research of the Food and Drug Administration between 1974 and 1988 were reviewed. There were 126 reports associated with the use of these drugs by metered-dose inhaler, which were consistent with a diagnosis of paradoxical bronchospasm. In addition, 58 such reports were received for these drugs delivered as a solution for nebulization between 1983 and 1988. Increased reporting of reactions consistent with paradoxical bronchospasm generally correlated with increased availability of these products during the same time period, although there has not been a steady upward trend in such reports for metered-dose inhalers during the past 3 years, despite increasing distribution figures. Despite the apparent infrequency of inhaler-induced paradoxical bronchospasm, the potentially life-threatening nature of such reactions makes awareness of this possibility essential. Patients who report that an inhaled beta-adrenergic agonist makes their asthma worse, as well as the patients who fail to demonstrate expected improvement with this form of therapy, should be suspected of having developed paradoxical bronchospasm.


Subject(s)
Adrenergic beta-Agonists/adverse effects , Bronchial Spasm/chemically induced , Adrenergic beta-Agonists/administration & dosage , Humans , Nebulizers and Vaporizers
12.
Ann Allergy ; 63(6 Pt 2): 578-84, 1989 Dec.
Article in English | MEDLINE | ID: mdl-2688496

ABSTRACT

Morbidity and mortality from asthma have been increasing in the United States and other countries. Although the reason for these changes is unknown, there are a number of possibilities. Authoritative reviews of epidemics of asthma deaths in other countries have focused on patient management, particularly the failure of patients and physicians to recognize the severity of the patients' asthma. Of great concern, however, has been the possibility that increases in asthma mortality reflect changes in the way that physicians treat asthma; most notably the use of multiple drug regimens (sometimes inappropriately) and dependence on inhaled beta agonists. Since most asthmatic patients are effectively and safely managed with present therapeutic modalities, it is essential that features that distinguish the fatality-prone asthmatic be characterized as distinctly as possible. It is reasonable to conclude that such a patient may be the patient whose asthma is not well defined, sometimes in terms of the diagnosis but more often in terms of the severity of their condition. This may be associated with a failure to utilize pulmonary function tests, and result in lack of an appropriate plan of action for exacerbations of asthma through cooperative management. As a result, there may be underutilization of corticosteroids, which are necessary for the treatment of inflammation associated with chronic asthma. Misunderstanding about the need to avoid external triggers and treat internal precipitants as well as inability to recognize the potential for medication-induced adverse effects may further characterize the fatality-prone asthmatic. Further studies are needed to confirm or to refute the speculative association between current management of asthmatic patients and morbidity and mortality.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Asthma/mortality , Asthma/epidemiology , Humans , Prospective Studies , United States
13.
Ann Allergy ; 63(6 Pt 2): 598-600, 1989 Dec.
Article in English | MEDLINE | ID: mdl-2688499

ABSTRACT

In summary, there are preclinical and clinical developmental periods during the study of new drugs. The latter is composed of three phases of study under an IND. The purpose of phase I is to show the initial safety of the drug. Efficacy should be demonstrated in phase II. Long-term studies in a large number of patients in phase III are designed to demonstrate the long-term safety and continued efficacy of the drug. Following review and acceptance that the data generated during these two developmental periods and submitted by the sponsor under an NDA demonstrate the safety and efficacy of the drug, the drug may be approved for marketing. If so, there will be continued evaluation of the drug during postmarketing surveillance. The phases of study that are required to demonstrate that a new drug is safe and efficacious are straightforward and clearly defined. The methods that are best used to satisfy these requirements are less clear and more open to interpretation by both sponsors and Agency reviewers. Guidelines for the testing of new drugs are extremely helpful in this regard, but will never (and probably never should) take the place of enlightened individual judgment on the part of investigators, sponsors, and FDA reviewers.


Subject(s)
Drug Evaluation , Drugs, Investigational , Humans , United States , United States Food and Drug Administration/organization & administration
14.
Allergy Proc ; 10(5): 349-56, 1989.
Article in English | MEDLINE | ID: mdl-2684756

ABSTRACT

Despite the increasing amount of data that has accumulated on sulfites as the intensity of medical interest has expanded in recent years, there are lingering, difficult, and, in most cases, as yet unresolved questions about sulfite sensitivity. These include questions about mechanism of action, prevalence, the most effective methods for protecting sulfite-sensitive patients from exposure to sulfites, and other issues. Perhaps the most important question, however, is whether sulfite sensitivity represents but one example of reactions that have occurred, are occurring, or will occur from exposure to additives and chemicals in the environment.


Subject(s)
Drug Hypersensitivity/etiology , Food Hypersensitivity/etiology , Food Preservatives/adverse effects , Sulfites/adverse effects , Anaphylaxis/etiology , Asthma/etiology , Humans
16.
J Allergy Clin Immunol ; 78(4 Pt 2): 806-11, 1986 Oct.
Article in English | MEDLINE | ID: mdl-2877018

ABSTRACT

Beta-adrenergic agonists, when administered alone or concomitantly with methylxanthines are capable of producing lesions of myocardial necrosis and an increased incidence of cardiac arrhythmias in several species of animals. These drugs, including "beta 2-specific" agonists, also have the potential to produce adverse cardiovascular effects when used clinically. In addition, beta agonists and methylxanthines can interact to potentiate or lessen effectiveness and theoretically increase the risk to the patient. As a result, the extent to which the concomitant administration of these drugs may contribute to adverse clinical effects needs further clarification.


Subject(s)
Adrenergic beta-Agonists/adverse effects , Theophylline/adverse effects , Animals , Asthma/drug therapy , Drug Interactions , Drug Therapy, Combination , Heart/drug effects , Humans
17.
Ann Allergy ; 54(5): 420-3, 1985 May.
Article in English | MEDLINE | ID: mdl-3994072

ABSTRACT

Recognition of sulfite sensitivity by the practicing physician has become increasingly important. A wide spectrum of reactions can occur after the ingestion or inhalation of sulfites in foods and medications. This case report of a 7-year-old child with sulfite sensitivity expands the patient population at risk even further.


Subject(s)
Drug Hypersensitivity/etiology , Sulfites/adverse effects , Child , Drug Hypersensitivity/diagnosis , Food Hypersensitivity/diagnosis , Humans , Skin Tests
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