ABSTRACT
OBJECTIVE: To evaluate the long-term efficacy and possible side effects of low doses of iodized oil on iodine nutrition and thyroid function in endemic goiter in Romania. METHODS: Random selection of 214 schoolchildren aged 6-14 years. Serial measurements of urinary iodine, thyroid volume with ultrasound, serum concentrations of thyrotropin, free thyroxine, thyroglobulin and thyroid autoantibodies before and up to 2 years after the oral administration of 200 mg iodine in iodized oil. RESULTS: Urinary iodine concentrations indicated a moderate iodine deficiency before therapy, sharply increased soon after therapy and slowly decreased thereafter but remained within the normal range up to more than 1 year after therapy. The prevalence of goiter was 29% before the administration of iodized oil and 9% 1 year later. Thyroid function tests and autoantibodies were normal before and up to 2 years after therapy. CONCLUSION: A single dose of 200 mg iodine from oral Lipiodol appears adequate and safe for correcting moderate iodine deficiency in children.
Subject(s)
Goiter, Endemic/diet therapy , Iodized Oil/therapeutic use , Adolescent , Child , Female , Humans , Iodide Peroxidase/blood , Iodide Peroxidase/immunology , Iodine/urine , Iodized Oil/administration & dosage , Iodized Oil/adverse effects , Male , Romania , Sodium Chloride, Dietary , Thyroid Function Tests , Thyrotropin/blood , Thyroxine/bloodABSTRACT
Some malignant tumours like testicular seminomas and ovarian dysgerminomas or medullar carcinoma of the breast, present an unusually lympho-histiocytic (TIL) rich stroma. Many reports have concluded that the prognosis for these patients is correlated with the intensity of TIL. Recently, some analyses consider that tumour-host interactions have a significant prognostic role in many other neoplasms. The presence of TIL may be a sign of less aggressive behaviour of some epithelial neoplasm like gastro-intestinal, pulmonary, mammary, urinary or cutaneous carcinomas (Wilson et al.). The aim of this study is a morphological and immunohistochemical (IHC) characterisation of the lympho-histiocytic populations of TIL in some gastro-intestinal and mammary carcinomas. The two localisation were chosen for their different contact with the exogene antigens and their possible different type of host's immune response.
Subject(s)
Adenocarcinoma/pathology , Breast Neoplasms/pathology , Carcinoma, Ductal/pathology , Colorectal Neoplasms/pathology , Lymphocytes, Tumor-Infiltrating/pathology , Stomach Neoplasms/pathology , Adenocarcinoma/metabolism , Antigens, CD20/metabolism , Breast Neoplasms/metabolism , Carcinoma, Ductal/metabolism , Colorectal Neoplasms/metabolism , Female , Humans , Leukocyte Common Antigens/metabolism , Lymphocyte Subsets/metabolism , Lymphocyte Subsets/pathology , Lymphocytes, Tumor-Infiltrating/metabolism , Microscopy, Electron, Transmission , Stomach Neoplasms/metabolismABSTRACT
Epidemiologic studies on school-children aged 6-16 years along 1978-1980 and in 1986, according to the WHO classification revealed the persistence of endemic goiter even in high incidence in some areas. Following UNICEF WHO recommendations, a new epidemiologic study was initiated in 30 counties for assessing urinary iodine through the spot urine sample method, which has widely been accepted as a satisfactory index of iodine intake. The urine samples were collected from lots of 100-200 children aged 6-16 years within each district. The results showed low iodine values, i.e., 2.4-5.5 micrograms/dl urine in 12 areas and 6-12.1 microgram/dl urine in the rest of the country. Comparison of the data on goiter endemic and iodine values in various counties shows lack of correlation in some areas. This prompted an extension of the study of urinary iodine over to larger groups of children in some counties.
