ABSTRACT
The cutaneous epithelioid angiomatous nodule is an uncommon benign vascular proliferation that has only recently been described. Clinically, it usually presents as a solitary, fast-growing, small reddish papulous or nodular lesion on the trunk or limbs of adults. Histopathologic study reveals a proliferation of epithelioid cells and predominantly solid, well delimited, unilobular growth in the superficial dermis. Well defined vessels are often found permeating the lesion, which also shows a certain degree of inflammatory infiltration. The cells contain abundant pink cytoplasm, often with vacuoles, and vesicular nuclei with prominent nucleoli. The morphology of these cells is relatively uniform, without atypia or pleomorphism, although mitoses are not uncommon. We report 2 new cases of cutaneous epithelioid angiomatous nodules, the first in a 28-year-old pregnant woman and the second in a 27-year-old man. In both cases, the usual characteristics of this entity were present, but with the peculiarity of a high mitotic index. We discuss the differential diagnosis of cutaneous epithelioid angiomatous nodules with other vascular proliferations that exhibit epithelioid cytology.
Subject(s)
Facial Neoplasms/pathology , Hemangioma/pathology , Pregnancy Complications, Neoplastic/pathology , Skin Neoplasms/pathology , Adult , Angiomatosis, Bacillary/diagnosis , Diagnosis, Differential , Facial Neoplasms/diagnosis , Female , Hemangioendothelioma, Epithelioid/diagnosis , Hemangioma/diagnosis , Hemangiosarcoma/diagnosis , Humans , Male , Pregnancy , Pregnancy Complications, Neoplastic/diagnosis , Shoulder , Skin Neoplasms/diagnosisABSTRACT
CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK cell lymphoma, is an aggressive and rare preculsor hematologic neoplasm recently recognized by the WHO-EORTC classification consensus for cutaneous lymphomas. The neoplasm tends to affect elderly patients, who usually present with skin lesions but often have a disseminated disease, including bone marrow involvement. Although the lesions are composed of cells with a lymphoblast-like morphology and an NK-cell phenotype, exhibiting a CD4+, CD56+ positive immunophenotype, recent studies support a relationship to plasmacytoid dendritic cells. Because of the rarity of this disease, we describe two patients suffering a CD4+/CD56+ hematodermic neoplasm.
Subject(s)
CD4 Antigens/immunology , CD56 Antigen/immunology , Hematologic Neoplasms/pathology , Skin Neoplasms/pathology , Skin/pathology , Aged , Humans , Male , Purpura/pathologyABSTRACT
This report describes the ultrasonic appearance of an ectopic pancreatic rest presenting as a mass within an intussusception due to an inverted Meckel diverticulum. Familiarity with the ultrasound appearance of this entity may be useful to obviate unnecessary imaging workup.