ABSTRACT
PURPOSE: Recursive partitioning analysis (RPA), a method of building decision trees of significant prognostic factors for outcome, was used to determine subgroups at significantly different risk for ipsilateral breast tumor recurrence (IBTR) in early-stage breast cancer. PATIENTS AND METHODS: Nine hundred twelve women underwent breast-conserving surgery, axillary dissection, and radiation. Systemic therapy was chemotherapy with or without tamoxifen in 32%, tamoxifen in 27%, or none in 41%. RPA was used to create a decision tree according to predictive variables that classify patients by IBTR risk, and the Kaplan-Meier method was used to calculate 10-year risks. Median follow-up was 5.9 years. RESULTS: Age was the first split in the partition tree. Patients more than 55 years old had a 4% 10-year IBTR, the only further division being use of tamoxifen or not (2% v 5%, P =.03). For patients
Subject(s)
Breast Neoplasms/pathology , Breast Neoplasms/therapy , Neoplasm Recurrence, Local/diagnosis , Actuarial Analysis , Adult , Age Factors , Aged , Aged, 80 and over , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Axilla/surgery , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Chemotherapy, Adjuvant , Combined Modality Therapy , Decision Trees , Female , Follow-Up Studies , Humans , Lymph Node Excision , Mastectomy, Segmental , Middle Aged , Prognosis , Risk Assessment , Tamoxifen/administration & dosageABSTRACT
A patient with a traumatic rupture of the right main bronchus is described. Successful surgical reconstruction of the torn airway, resulting in functional improvement, was performed 7 years after the injury.
