ABSTRACT
Cancer of the female breast is one of the leading types of cancers worldwide. This paper presents a case study of Malwa Belt in India that has witnessed the proliferation in the overall mortality rate due to breast cancer. The paper researches mortality aspect of the disease and its association with the various risk parameters including demographic characteristics, percentage of pesticides residue present in the water and soil, life style of the women in the affected area, water intake, and the amount of pesticide exposure to the patient. The levels of organochlorine pesticides like DDT and its metabolites and isomers of HCH in blood, tumor and surrounding adipose are estimated. Additionally, an extent of exposure of the subjects to environmental pollutants like heavy metals (Lead, Copper, Iron, Zinc, Calcium, Selenium, and Chromium etc.)are also examined. For the obtained experimental data, an efficient ensemble machine learning based framework called Bagoost is proposed to predict the risk of breast cancer in Malwa women. The performance of the proposed machine learning model results in an accuracy of 98.21 percent, when empirically tested using K-fold cross validation over the real time data of malignant and benign cases and is established to be efficacious than the existing approaches.
Subject(s)
Breast Neoplasms , Hydrocarbons, Chlorinated , Pesticides , Female , Humans , Hydrocarbons, Chlorinated/analysis , Machine Learning , Pesticides/adverse effects , Pesticides/analysisABSTRACT
Background@#The efficacy of local anesthesia decreases in patients with symptomatic irreversible pulpitis. Therefore, it was proposed that the use of premedication with an anti-inflammatory drug might increase the success rate of pulpal anesthesia in mandibular posterior teeth with vital inflamed pulp. @*Methods@#One hundred thirty-four patients who were actively experiencing pain willingly participated in this study. The Heft Parker (HP) visual analog scale (VAS) was used to record the initial pain intensity. Patients were randomly allocated to receive a placebo, 10 mg of ketorolac, and 650 mg of paracetamol. The standard inferior alveolar nerve block (IANB) was administered to all patients using 2% lidocaine with 1:200,000 adrenaline after one hour of medication. After 15 min, the patient was instructed to rate the discomfort during each step of the treatment procedure, such as access to remaining dentin, access to the pulp chamber, and during canal instrumentation on the HP VAS. IANB was considered successful if the patient reported no or mild pain during access preparation and instrumentation. Moderate or severe pain was classified as a failure of IANB and another method of anesthesia was used before continuing the treatment. @*Results@#The rate of successful anesthesia in the placebo, paracetamol, and ketorolac groups was 29%, 33%, and 43%, respectively, and no statistically significant difference was found between the groups. @*Conclusion@#Preoperative administration of paracetamol or ketorolac did not significantly affect the success rate of IANB in patients with irreversible pulpitis. No significant difference was observed between the paracetamol and ketorolac groups.
ABSTRACT
Background@#The efficacy of local anesthesia decreases in patients with symptomatic irreversible pulpitis. Therefore, it was proposed that the use of premedication with an anti-inflammatory drug might increase the success rate of pulpal anesthesia in mandibular posterior teeth with vital inflamed pulp. @*Methods@#One hundred thirty-four patients who were actively experiencing pain willingly participated in this study. The Heft Parker (HP) visual analog scale (VAS) was used to record the initial pain intensity. Patients were randomly allocated to receive a placebo, 10 mg of ketorolac, and 650 mg of paracetamol. The standard inferior alveolar nerve block (IANB) was administered to all patients using 2% lidocaine with 1:200,000 adrenaline after one hour of medication. After 15 min, the patient was instructed to rate the discomfort during each step of the treatment procedure, such as access to remaining dentin, access to the pulp chamber, and during canal instrumentation on the HP VAS. IANB was considered successful if the patient reported no or mild pain during access preparation and instrumentation. Moderate or severe pain was classified as a failure of IANB and another method of anesthesia was used before continuing the treatment. @*Results@#The rate of successful anesthesia in the placebo, paracetamol, and ketorolac groups was 29%, 33%, and 43%, respectively, and no statistically significant difference was found between the groups. @*Conclusion@#Preoperative administration of paracetamol or ketorolac did not significantly affect the success rate of IANB in patients with irreversible pulpitis. No significant difference was observed between the paracetamol and ketorolac groups.
