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1.
Zhongguo Zhong Yao Za Zhi ; 47(13): 3526-3529, 2022 Jul.
Article in Chinese | MEDLINE | ID: mdl-35850805

ABSTRACT

One new phenylethanoid glycoside was isolated from the ethyl acetate fraction of the 75% EtOH extract of Forsythiae Fructus by various column chromatographies(HP20, silica gel, ODS) and preparative HPLC.Its structure was identified as forsythiayanoside E(1) by physicochemical properties and extensive spectroscopic analysis(HR-ESI-MS, 1 D and 2 D NMR).Compound 1 was evaluated for cytotoxic activities by MTT assay and showed weak cytotoxic activity against MCF-7 and A-375 cell lines with inhibition rates of 39.85% and 43.38% at 40 µmol·L~(-1), and no cytotoxic activity against PC-3 and HepG2 cell lines at 100 µmol·L~(-1).


Subject(s)
Cardiac Glycosides , Glycosides , Cardiac Glycosides/analysis , Chromatography, High Pressure Liquid , Fruit/chemistry , Glycosides/analysis , Glycosides/pharmacology , Molecular Structure , Plant Extracts/chemistry
2.
J Asian Nat Prod Res ; 24(5): 496-502, 2022 May.
Article in English | MEDLINE | ID: mdl-34581213

ABSTRACT

Two new flavonol glycosides 3,5,7-trimethoxyflavone-4'-O-[5'''-O-p-coumaroyl-ß-D-apiofuranoyl-(1'''→2'')-ß-D-glucopyranoside] (1) and 3,5,7-trimethoxyflavone -4'-O-ß-D-glucopyranoside (2) were isolated from Selaginella tamariscina. The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS spectrometry. Two compounds were evaluated for cytotoxic activities against A-375, MCF-7, MDA-MB-231 and MDA-MB-468 cell lines by MTT assay. Unfortunately, two compounds displayed no cytotoxic activities.


Subject(s)
Selaginellaceae , Flavonols/chemistry , Flavonols/pharmacology , Glycosides/chemistry , Glycosides/pharmacology , Magnetic Resonance Spectroscopy , Molecular Structure , Selaginellaceae/chemistry
3.
Zhongguo Zhong Yao Za Zhi ; 47(24): 6641-6646, 2022 Dec.
Article in Chinese | MEDLINE | ID: mdl-36604913

ABSTRACT

Four phenylethanoid glycosides were isolated from the 75% EtOH extract of Forsythiae Fructus by various column chromatography methods(MCI, silica gel, ODS and semi-preparative HPLC). Their structures were identified as forsythenside M(1), forsythenside K(2), forsythoside I(3) and forsythoside A(4) by physicochemical properties and extensive spectroscopic analysis(UV, 1 D and 2 D NMR, HR-ESI-MS). Among them, compound 1 was one new phenylethanoid glycoside. The in vitro cytotoxic activities of these compounds against MCF-7, A-375, SGC-7901 and B16 F10 were evaluated. The results showed that compounds 1-4 had cytotoxic activities against MCF-7, A-375, SGC-7901 and B16 F10 at 40 µmol·L~(-1).


Subject(s)
Cardiac Glycosides , Plant Extracts , Plant Extracts/chemistry , Glycosides/analysis , Cardiac Glycosides/analysis , Fruit/chemistry , Magnetic Resonance Spectroscopy , Molecular Structure
4.
J Asian Nat Prod Res ; 23(7): 675-680, 2021 Jul.
Article in English | MEDLINE | ID: mdl-32869691

ABSTRACT

Two new selariscinins named selariscinin F (1) and selariscinin G (2), along with one known selariscinin D (3) were isolated from Selaginella tamariscina. The structures of 1-3 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS.


Subject(s)
Selaginellaceae , Magnetic Resonance Spectroscopy , Molecular Structure
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