1.
Comput Biol Chem
; 29(3): 220-8, 2005 Jun.
Article
in English
| MEDLINE
| ID: mdl-15979042
ABSTRACT
This paper applies discrete wavelet transform (DWT) with various protein substitution models to find functional similarity of proteins with low identity. A new metric, 'S' function, based on the DWT is proposed to measure the pair-wise similarity. We also develop a segmentation technique, combined with DWT, to handle long protein sequences. The results are compared with those using the pair-wise alignment and PSI-BLAST.