ABSTRACT
The aim of this study was to estimate the prevalence of the different types of eardrum pathology in a cohort (cohort 1955) who were children before the era of ventilation tubes, and to compare these findings with the prevalence of eardrum pathology in a previous published cohort study on 222 children followed since the age of four years (cohort 1975) in the era of ventilation tubes. All inhabitants of Hillerød county born in 1955 were invited to a screening examination including otomicroscopy, tympanometry and audiometry. All eardrum pathology was recorded. In cohort 1955, 59% of 460 possible, attended the examination. In addition 9% returned a questionnaire enquiring their otologic history. In the cohort with no grommets, retraction of Shrapnell's membrane was found in 4% of the ears compared to 20% in the cohort with grommets. Tensa pathology was found in 6% of the ears in the old cohort and in 24% in the young cohort. Despite the increased attention to the diagnosis of secretory otitis, and the increased rate of surgical treatment, the prevalence of eardrum pathology seems to have increased. The reason for this increase is discussed.
Subject(s)
Otitis Media with Effusion/complications , Tympanic Membrane/pathology , Acoustic Impedance Tests , Adolescent , Adult , Audiometry , Barotrauma , Child , Cohort Studies , Denmark/epidemiology , Follow-Up Studies , Humans , Incidence , Middle Ear Ventilation , Otitis Media with Effusion/diagnosis , Otitis Media with Effusion/therapy , Surveys and QuestionnairesABSTRACT
The influence of experimental rhinitis on the absorption of buserelin, measured as the serum luteinizing hormone (LH) response, has been investigated. A single dose of 200 micrograms buserelin was given to 24 healthy male volunteers after induction of experimental rhinitis with histamine and after use of a saline spray (placebo control). Except on one occasion, when the pump-spray apparently was incorrectly operated, serum LH concentration rose after buserelin. There was no difference in the LH response between histamine-induced rhinitis and saline controls. It was concluded that intranasal application of buserelin represents a reliable mode of application and that modification of the administration route or a change in the dosage schedule during naturally-occurring nasal inflammations, such as the common cold and allergic rhinitis, is unnecessary in patients undergoing chronic treatment with intranasal buserelin, e.g. for prostatic cancer, endometriosis, precocious puberty, and contraception.
