ABSTRACT
The operation second-look was carried out on 66 women with ovarian cancer without any clinical symptoms of disease. 14 of them (21.2%) showed persistent cancer, including 5-cancer in early stages. The level of CA 125 didn't exceed 35 U/ml in 60 women, and in 5 women persistent cancer wasn't detected during the second-look operation. Negative result of second-look operation doesn't inform about recovery because in 8 women out of 52 recurrence of cancer reported.
Subject(s)
Neoplasm Recurrence, Local/surgery , Ovarian Neoplasms/surgery , Adult , Biomarkers, Tumor/analysis , CA-125 Antigen/analysis , Female , Humans , Incidence , Middle Aged , Neoplasm Recurrence, Local/epidemiology , Neoplasm Staging , Ovarian Neoplasms/metabolism , Ovarian Neoplasms/pathology , ReoperationABSTRACT
CA 125 levels were estimated by immunoenzymatic technique: in fluids obtained by puncturing benign ovarian cysts under guidance of USG and in the patients' sera (23 cases); in serum and in ascites of 39 ovarian cancer patients at the IIIrd or IV th stage of clinical advance; in the content of malignant tumors in the course of surgery (in 16 of the above listed patients). Ca 125 level was significantly lower in the content of benign Cysts as compared to malignant ones. CA 125 level higher than 1000/ml pointed to a malignant process. Both in serum and in ascites, more advanced tumors and tumors showing progression manifested higher levels of the marker than less advanced tumors and tumors characterized as stable disease. In the group of patients analysis of CA 125 levels provided less information on the disease course than in individual cases.
Subject(s)
Antigens, Tumor-Associated, Carbohydrate/analysis , Antigens, Tumor-Associated, Carbohydrate/blood , Ovarian Cysts/blood , Ovarian Cysts/immunology , Ovarian Neoplasms/blood , Ovarian Neoplasms/immunology , Ascites/blood , Ascites/immunology , Exudates and Transudates/immunology , Female , Humans , Immunoenzyme Techniques , Neoplasm Staging , Ovarian Cysts/diagnostic imaging , Ovarian Neoplasms/drug therapy , Ovarian Neoplasms/pathology , Ovarian Neoplasms/surgery , Ultrasonography, InterventionalABSTRACT
Local treatment was administrated to 130 women, in whom colposcopy, cytology and (if the latter was abnormal) histology pointed to HPV infection in uterine cervix. The best results were obtained with 13-cis-retinoic acid (provitamin A) in conjunction with interferon beta (94.2% cured patients), followed by interferon beta in combination with TFX (90% cured patients) and interferon beta administered alone (88% cured patients).
