ABSTRACT
BACKGROUND: In this study we present the Tracking Accessory 3 (TA3) as an alternative to the commercial gating block (GB) surrogate for the Varian Truebeam™ gating system (TGS). The TGS requires three visible reflectors to track the surrogate, presenting an opportunity for a surrogate to be made with less material and thus smaller dosimetric footprint than the commercial four reflector model. MATERIALS AND METHODS: Relative dose and depth dose profiles below the TA3 and the GB were measured with radiosensitive film. Accuracy and reproducibility of the detected motion amplitude for three TA3s and one GB were determined using a respiratory phantom with surrogate to determine the camera's tracking volume. Clinical performance was evaluated prospectively in 10 breast cancer patients treated with deep inspiration breath hold monitored with TA3 and compared to previously published results. Non-parametric statistics were applied to test for significance. RESULTS AND CONCLUSIONS: Surface doses were increased up to 94% and 187% for the TA3 and GB, respectively, compared to no surrogate. The surface area influenced by at least 25% increase in dose was 12 cm2 and 105 cm2 for the TA3 and GB, respectively. The water equivalent thickness of the surrogates was found to be 1 mm for the TA3 and 3 mm for GB. The difference in measured amplitude were <0.2 mm for TA3 compared to the GB. The TA3s and GB were detected at all extremes of the clinically relevant tracking volume of the TGS. Clinical performance showed no significant differences. The TA3 caused less surface dose increase compared to the commercial GB. In the tested range all surrogates measured motion amplitude within 0.2 mm of reference value, which is not a clinically relevant difference. The TA3 showed no significant differences in clinical performance to similarly positioned surrogates.
Subject(s)
Breast Neoplasms , Humans , Female , Reproducibility of Results , Motion , Carbon , Radiotherapy Planning, Computer-Assisted/methodsABSTRACT
BACKGROUND AND PURPOSE: Adjuvant radiotherapy of internal mammary nodes (IMN) improves survival in high-risk early breast cancer patients but inevitably leads to more dose to heart and lung. Target coverage is often compromised to meet heart/lung dose constraints. We estimate heart and lung dose when target coverage is not compromised in consecutive patients. These estimates are used to guide the choice of selection criteria for the randomised Danish Breast Cancer Group (DBCG) Proton Trial. MATERIALS AND METHODS: 179 breast cancer patients already treated with loco-regional IMN radiotherapy from 18 European departments were included. If the clinically delivered treatment plan did not comply with defined target coverage requirements, the plan was modified retrospectively until sufficient coverage was reached. The choice of selection criteria was based on the estimated number of eligible patients for different heart and lung dose thresholds in combination with proton therapy capacity limitations and dose-response relationships for heart and lung. RESULTS: Median mean heart dose was 3.0 Gy (range, 1.1-8.2 Gy) for left-sided and 1.4 Gy (0.4-11.5 Gy) for right-sided treatment plans. Median V17Gy/V20Gy (hypofractionated/normofractionated plans) for ipsilateral lung was 31% (9-57%). The DBCG Radiotherapy Committee chose mean heart dose ≥ 4 Gy and/or lung V17Gy/V20Gy ≥ 37% as thresholds for inclusion in the randomised trial. Using these thresholds, we estimate that 22% of patients requiring loco-regional IMN radiotherapy will be eligible for the trial. CONCLUSION: The patient selection criteria for the DBCG Proton Trial are mean heart dose ≥ 4 Gy and/or lung V17Gy/V20Gy ≥ 37%.
ABSTRACT
Imaging ellipsometry (IE) has been applied to generate laterally resolved thickness maps of spin-coated membranes in both the dry and fully hydrated state. Spin-coating offers a convenient preparation method for stacked supported membranes, and in-depth thickness maps for such films can be measured by IE, thereby going beyond topography measurements of the top surface. We find that dry lipid films of POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) have a highly ordered multilamellar structure which allows counting of the number of individual bilayers in a thick film from the progression in a concentration series. The average film thickness is approximately proportional to the coating concentration with a constant of proportionality of 5.2 nm/mM and 6.2 nm/mM for POPC and DSPC (1,2-distearoyl-sn- glycero-3-phosphocholine), respectively. The root-mean-square roughness of the dry films is also approximately proportional to concentration with constants of 3.7 nm/mM (DSPC) and 0.87 nm/mM (POPC). Fully hydrated POPC membranes with several stacked bilayers show decreasing thickness for increasing temperature. An apparent excess in thickness by 1.2 nm for the proximal membrane can possibly be linked to the presence of a structured water film next to the solid support. This is supported by modeling of spectroscopic data. Thickness maps of double supported ternary membranes show resolvable liquid-ordered domains in the second membrane while domains are below the resolution limit in the proximal membrane. A thickness difference of 1.69 and 1.89 nm between the liquid-ordered (lo) and liquid-disordered (ld) phases is found for two different ternary membrane compositions. This is approximately twice the height difference measured by AFM on domains, thus indicating that the relative excess thickness of the lo phase is symmetrically distributed.
