1.
J Org Chem
; 70(10): 4038-42, 2005 May 13.
Article
in English
| MEDLINE
| ID: mdl-15876094
ABSTRACT
[reaction: see text] Details of a synthesis of dihydrofurans using gamma-substituted chiral allenamides are described here. Some transformations of these dihydrofurans are also examined including a highly stereoselective dihydroxylation and a rare account of a Lewis acid-mediated removal of an N-acyl substituent at the anomeric carbon of a tetrahydrofuran ring system. These studies provide further support for the synthetic utility of allenamides.