Subject(s)
Cryoglobulinemia/complications , Hepatitis C, Chronic/complications , Kidney Failure, Chronic/complications , Biopsy , Glomerulonephritis, Membranoproliferative/complications , Glomerulonephritis, Membranoproliferative/pathology , Humans , Kidney/pathology , Kidney Failure, Chronic/pathology , Kidney Failure, Chronic/therapy , Male , Middle Aged , Plasmapheresis , Renal DialysisSubject(s)
Humans , Male , Middle Aged , Cryoglobulinemia/complications , Hepatitis C, Chronic/complications , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/pathology , Renal Insufficiency, Chronic/therapy , Biopsy , Glomerulonephritis, Membranoproliferative/complications , Glomerulonephritis, Membranoproliferative/pathology , Kidney/pathology , Plasmapheresis/methods , Renal Dialysis/methodsABSTRACT
Renal cell carcinoma is infrequent in children; consequently it is important to communicate its diagnosis and follow up. The behavior of this type of tumor is better characterized in adults and in this setting the treatment of choice is surgical resection. However, chemo- and radiotherapy for metastatic tumors has not been well defined. Our objective was to report the experience of a single pediatric institution in the diagnosis and treatment of renal cell carcinoma and to review the literature on this subject. We retrospectively reviewed patients diagnosed with renal cell carcinoma in the last twenty years. Only three patients were found, and we describe their clinical features and therapeutic approach. Although renal cell carcinoma is rare in children, clinical suspicion of this disease in children older than 5 years with renal masses is very important since the diagnostic and therapeutic approach differs from that for Wilms' tumor. The main prognostic factors seem to be staging and complete resection. Multicenter collaboration is required to standardize the treatment of tumors in advanced stages and to define the role of allogeneic stem cell transplantation in metastatic tumors.
Subject(s)
Carcinoma, Renal Cell/diagnosis , Kidney Neoplasms/diagnosis , Adolescent , Child , Humans , Male , Retrospective StudiesABSTRACT
El carcinoma renal es poco frecuente en niños, por lo que es importante comunicar el diagnóstico y seguimiento de estos casos. Su comportamiento en adultos es más conocido, y se sabe que el tratamiento de elección es la extirpación quirúrgica. Sin embargo, el tratamiento de los tumores metastásicos con quimioterapia y/o radioterapia no está bien definido. Nuestro objetivo es aportar la experiencia de un centro en el diagnóstico y tratamiento del carcinoma renal pediátrico, así como revisar la bibliografía al respecto. Se revisan de forma retrospectiva los pacientes diagnosticados de carcinoma renal en los últimos 20 años. La muestra está formada por 3 niños, y se describen las características clínicas de los pacientes y su tratamiento. Se insiste en que aunque el carcinoma renal es una entidad rara en niños, es importante sospecharlo en pacientes mayores de 5 años con masas renales, ya que la aproximación diagnóstica y terapéutica difiere del tumor de Wilms. La estadificación y la resección completa parecen ser los factores pronósticos fundamentales. Es necesaria la colaboración de varios centros para la estandarización del tratamiento de los tumores en estadios avanzados, valorando el papel del trasplante alogénico de progenitores hematopoyéticos en tumores metastásicos (AU)
Subject(s)
Child , Adolescent , Male , Humans , Postpericardiotomy Syndrome , Time Factors , Retrospective Studies , Recurrence , Anti-Inflammatory Agents, Non-Steroidal , Carcinoma, Renal Cell , Diagnosis, Differential , Ibuprofen , Electrocardiography , Follow-Up Studies , Kidney NeoplasmsABSTRACT
Middle ear neuroendocrine neoplasms are rare and of benign behaviour. Diagnosis is difficult since they produce non-specific symptoms. Electron microscopy and immunochemistry are necessary. We present a carcinoid tumor in a 28-year-old man with one side deafness. He underwent tympanoplasty, staying free of recurrences two years and a half later.
Subject(s)
Carcinoid Tumor/pathology , Ear Neoplasms/pathology , Ear, Middle/pathology , Neuroendocrine Tumors/pathology , Adult , Carcinoid Tumor/diagnosis , Carcinoid Tumor/surgery , Ear Neoplasms/diagnosis , Ear Neoplasms/surgery , Ear, Middle/surgery , Humans , Male , Neuroendocrine Tumors/diagnosis , Neuroendocrine Tumors/surgery , Prognosis , Tomography, X-Ray ComputedABSTRACT
Embryonal rhabdomyosarcoma of the bladder is a tumor thar presents sporadically in the adult patient and its treatment continues to be a controversy. One such case is presented herein. The epidemiological and histopathological features of this tumor type are described and the different therapeutic approaches advocated in the literature are discussed.
Subject(s)
Rhabdomyosarcoma, Embryonal , Urinary Bladder Neoplasms , Aged , Humans , Male , Rhabdomyosarcoma, Embryonal/classification , Rhabdomyosarcoma, Embryonal/diagnosis , Urinary Bladder Neoplasms/classification , Urinary Bladder Neoplasms/diagnosisABSTRACT
Necrosing vasculitis and, within it, nodosa polyarteritis, is an infrequent entity characterized by the absence of pathognomonic signs and symptoms, but which can potentially affect the entire body. The initial description was made by Kussmaul and Maier in 1866. Sings and symptoms of this clinical picture are not frequently circumscribed to the urinary tract. We describe here one case of a particularly infrequent presentation, as a vesical mass with gross haematuria. The paper discusses the clinical picture, diagnosis and treatment of this process.
Subject(s)
Polyarteritis Nodosa , Urinary Bladder Diseases , Humans , Male , Middle Aged , Polyarteritis Nodosa/diagnosis , Polyarteritis Nodosa/therapy , Urinary Bladder Diseases/diagnosis , Urinary Bladder Diseases/therapyABSTRACT
We record a case of an 18 year old female patient with a history of asymptomatic, keratotic, waxy papules localized over the thenar and hypothenar eminence of palms and the internal aspect of the soles of feet. Histologically they were characterized by hyperkeratosis, acanthosis, elastorrexis and enlarged collagen fibers, typical of the picture known as Costa's acrokeratoelastoidosis. We establish a differential diagnosis with other clinically similar keratotic conditions.
Subject(s)
Acrodermatitis/pathology , Keratosis/pathology , Skin Diseases, Vesiculobullous/pathology , Acrodermatitis/complications , Adolescent , Female , Humans , Keratosis/complications , Skin Diseases, Vesiculobullous/complicationsABSTRACT
Twenty seven children were followed up prospectively after renal transplant for evidence of infection and illness due to cytomegalovirus (CMV), Epstein-Barr virus (EBV) and varicella zoster virus (VZV). Virus shedding and serological status were tested at transplant day, biweekly for two months, monthly for six months and trimestrialy thereafter. Determinations were done by complement fixation test. CMV isolation was established by microscopic examination of urinary cultures. Primary infections were objetivated in 27 cases (18 CMV, 1 EBV, 8 VZV) and reinfection in 3 (2 CMV, 1 VZV). Irreversible allograft rejection related to infection was disclosed in 2 patients (1 primary CMV infection, 1 VZV reinfection). Renal function impairment occurred only with CMV (6 primary and 1 secondary infections). One patient died with CMV over infection.
