[Analysis of hormone profile in women during the pre- and postmenopausal period using hormone replacement therapy, and analysis of the mammography image in these women]. / Analiza profilu hormonalnego u kobiet w okresie przed- i pomenopauzalnym stosujacych hormonalna terapie zastepcza, oraz analiza obrazu mammograficznego u tych kobiet.

The hormonal profile and mammography results were analysed in 120 women in premenopause (group A) and 130 in postmenopausal period (group B). The analysis developed biphasic menstrual cycle, with high progesterone levels in the second cycle's period in 57 subjects (group A--mean P concentration--53.7 nmol/ml), and elevated E2 levels in monophasic cycle in 63 subjects (group A2--man E2 205.4 pg/dl). In case of post-menopausal women mean E2 level during therapy was 104.6 pg/dl. In examined group 8 subject have been undergoing hormonal replacement therapy for 1-3 years, 30 of them for 5 years, 20 more than 5 years. In mammography in one case from group A1 with high progesterone concentration abnormally opaqueness has been observed. Histological examination confirmed incidence of cancer cells. No other changes have been observed. High serum progesterone concentration in pre-menopausal women increase risk of cancer.

[Effects of oral administration of estrogen replacement therapy in surgical menopause]. / Wczesna pooperacyjna doustna estrogenoterapia zastepcza u pacjentek po usunieciu macicy z przydatkami.

OBJECTIVE: The aim of this study was to analyze effects of oral administration of conjugated estrogens in women after surgical menopause. MATERIAL AND METHODS: A prospective study that included 41 women after hysterectomy with bilateral oophorectomy, was performed. All patients received conjugated estrogens (Premarin) 0.625 mg daily from second or third days after surgery. Plasma level of estradiol, FSH and several homeostatic parameters were evaluated before and after 2, 5 days and 6 weeks of hormone therapy. The symptoms of climacteric syndrome were estimated based on the scale of Kuppermann. RESULTS: A decrease in plasma estradiol levels in early postoperative days and an increase up to 100 pg/ml in estradiol concentration after 6 weeks of estrogen therapy were observed. Changes in platelet number, plasma concentration of coagulation factors were transient and there were no significant thrombophilic effects after 6 weeks of Premarin administration. CONCLUSIONS: The postoperative oral administration of conjugated estrogens did not cause thromboembolic complications among women after surgical menopause. Early beginning of estrogen replacement therapy after hysterectomy may prevent symptoms of climacteric syndrome occurrence.