Fates of Emitted Particles Depending on Mask Wearing Using an Approach Validated Across Spatial Scales.

The spread of emitted potentially virus-laden aerosol particles is known to be highly dependent on whether a mask is worn by an infected person and on the emission scenario, i.e., whether the person is coughing, speaking, or breathing. The aim of this work is to investigate in detail the fates of particles emitted by a person wearing a perfectly fitting, a naturally fitted mask with leakage, and no mask depending on the emission scenario. Therefore, a two-scale numerical workflow is proposed where parameters are carried through from a micro-scale where the fibers of the mask filter medium and the aerosol particles are resolved to a macro-scale and validated by comparison to experimental measurements of fractional filtration efficiency and pressure drop of the filter medium as well as pressure drop of the mask. It turns out that masks reduce the number of both emitted and inhaled particles significantly even with leakage. While without a mask, the person opposite of an infected person is generally at the highest risk of being infected, a mask worn by an infected person speaking or coughing will deflect the flow leading to the fact that the person behind the infected person might inhale the largest number of aerosol particles.

Face mask performance related to potentially infectious aerosol particles, breathing mode and facial leakage.

During the COVID 19 pandemic, wearing certified Respiratory Protective Devices (RPDs) provided important means of protection against direct and indirect infections caused by virus-laden aerosols. Assessing the RPD performance associated with infection prevention in standardised certification tests, however, faces drawbacks, such as the representativeness of the test aerosols used, the protection of third parties during exhalation or the effect of facial leaks. To address these drawbacks, we designed a novel test bench to measure RPD performance, namely the number based total efficiency, size-segregated fractional filtration efficiency and net pressure loss, for 11 types of certified surgical masks and Filtering Face Pieces dependent on breathing mode and facial fit. To be representative for the context of potentially infectious particles, we use a test aerosol based on artificial saliva that is in its size distribution similar to exhaled aerosols. In inhalation mode excluding facial leaks, all investigated samples deposit by count more than 85% of artificial saliva particles, which suggests a high efficiency of certified RPD filter media related to these particles. In exhalation mode most RPDs tend to have similar efficiencies but lower pressure losses. This deviation tends to be significant primarily for the RPDs with thin filter layers like surgical masks or Filtering Face Pieces containing nanofibers and may depend on the RPDs shape. Both the filtration efficiency and pressure loss are strongly inter-dependent and significantly lower when RPDs are naturally fitted including facial leaks, leading to a wide efficiency range of approximately 30-85%. The results indicate a much greater influence of the facial fit than the filter material itself. Furthermore, RPDs tend be more effective in self-protection than in third-party protection, which is inversely correlated to pressure loss. Comparing different types of RPDs, the pressure loss partially differs at similar filtration efficiencies, which points out the influence of the material and the filter area on pressure loss.

A multi-layered strategy for COVID-19 infection prophylaxis in schools: A review of the evidence for masks, distancing, and ventilation.

Implications for the academic and interpersonal development of children and adolescents underpin a global political consensus to maintain in-classroom teaching during the ongoing COVID-19 pandemic. In support of this aim, the WHO and UNICEF have called for schools around the globe to be made safer from the risk of COVID-19 transmission. Detailed guidance is needed on how this goal can be successfully implemented in a wide variety of educational settings in order to effectively mitigate impacts on the health of students, staff, their families, and society. This review provides a comprehensive synthesis of current scientific evidence and emerging standards in relation to the use of layered prevention strategies (involving masks, distancing, and ventilation), setting out the basis for their implementation in the school environment. In the presence of increasingly infectious SARS-Cov-2 variants, in-classroom teaching can only be safely maintained through a layered strategy combining multiple protective measures. The precise measures that are needed at any point in time depend upon a number of dynamic factors, including the specific threat-level posed by the circulating variant, the level of community infection, and the political acceptability of the resultant risk. By consistently implementing appropriate prophylaxis measures, evidence shows that the risk of infection from in-classroom teaching can be dramatically reduced. Current studies indicate that wearing high-quality masks and regular testing are amongst the most important measures in preventing infection transmission; whilst effective natural and mechanical ventilation systems have been shown to reduce infection risks in classrooms by over 80%.

Inactivation of aerosolized SARS-CoV-2 by 254 nm UV-C irradiation.

Surface residing SARS-CoV-2 is efficiently inactivated by UV-C irradiation. This raises the question whether UV-C-based technologies are also suitable to decontaminate SARS-CoV-2- containing aerosols and which doses are needed to achieve inactivation. Here, we designed a test bench to generate aerosolized SARS-CoV-2 and exposed the aerosols to a defined UV-C dose. Our results demonstrate that the exposure of aerosolized SARS-CoV-2 with a low average dose in the order of 0.42-0.51 mJ/cm2 UV-C at 254 nm resulted in more than 99.9% reduction in viral titers. Altogether, UV-C-based decontamination of aerosols seems highly effective to achieve a significant reduction in SARS-CoV-2 infectivity.

Generation, characterization, and comparison of human exhaled and technical aerosols for the evaluation of different air-purifying technologies against infectious aerosols.

In light of the COVID-19 pandemic, the importance of protective measures against infectious aerosols has drastically increased, as the transmission of diseases via airborne particles is impacting many aspects of everyday life. The protective measures against such infections are determinant in the operation of schools and kindergartens, hygiene in hospitals and medical facilities, in offices, administrative and production facilities, hotels, and the event industry, among others. To test these protective measures, suitable test aerosols and processes are needed. These aerosols ought to be similar to aerosols exhaled by humans as those carry the pathogens and thus need to be removed from the air or inactivated. The exhaled aerosols of several healthy test subjects were characterized by their particle concentration and size distribution. In previous studies, it was found that exhaled particle concentration varies significantly from subject to subject and most of the particles can be found in the submicron size range. Aerosols technically generated through nebulization were emitted by the generators in particle concentrations several orders of magnitude higher than those exhaled by humans, independent of the aerosol generation method and nebulized fluid. The particle size distribution generated by the two nebulizers used, however, was quite similar to the measured size distributions of the human aerosols, with most of the particles below 1 µm in size. Consequently, the used aerosol generators are not suitable to mimic single individuals as active aerosol sources, but rather to provide a sufficient amount of aerosol similar to human aerosols in size distribution, which can be used in the testing of air purification technologies.

[Aerosols and SARS-CoV-2: Statement of the "Expert Group Aerosols" on the development, infectivity, spread and reduction of airborne, virus-containing particles in the air]. / Stellungnahme des "Expertenkreises Aerosole": Aerosole und SARS-CoV-2 ­ Entstehung, Infektiosität, Ausbreitung und Minderung luftgetragener, virenhaltiger Teilchen in der Atemluft.

Aerosols are currently seen as one of the main transmission routes for SARS-CoV-2, but a comprehensive understanding of the processes and appropriate action/adaptation of protection concepts requires the exchange of information across interdisciplinary boundaries. Against this background, the Baden-Württemberg state government launched in October 2020 a multidisciplinary "Expert Group Aerosols" comprising engineers, natural scientists and medical professionals. In its statement, the group has compiled the current state of knowledge in all relevant disciplines in the context of airborne SARS-CoV-2 infection. In addition to the well-known hygiene and social distancing rules, the importance of the correct use of effective masks is emphasized. Furthermore, the necessity for dynamic and correct ventilation is pointed out and illustrated with ventilation intervals and periods for different scenarios as examples. The effectiveness of stationary or mobile cabin air filters as an important component in the protection concept is discussed. The first opinion of the expert group makes it clear that the existing hygiene and social distancing rules offer the best possible protection against SARS-CoV-2 infection only when correctly applied in combination.

Reducing indoor particle exposure using mobile air purifiers-Experimental and numerical analysis.

Aerosol particles are one of the main routes of transmission of COVID-19. Mobile air purifiers are used to reduce the risk of infection indoors. We focus on an air purifier that generates a defined volumetric air flow through a highly efficient filter material. We investigate the transport of aerosol particles from an infected dummy equipped with an aerosol generator to receiving thermal dummies. For analysis, we use up to 12 particle sensors to monitor the particle concentration with high spatial resolution. Based on the measurement data, a computational fluid dynamics (CFD) model is set up and validated. The experimental and numerical methods are used to investigate how the risk of infection suggested by the particle exposure in an exemplary lecture hall can be reduced by a clever choice of orientation of the air purifier. It turns out that obstructing the outlet stream of the air purifier may be particularly advantageous. The particle concentration at the head height deviates by 13% for variations of the location and orientation. At an air change per hour of 5, the cumulated PM1 mass at the head level was reduced by 75%, independently of the location of the infected dummy, compared to the "natural decay" case, showing that filtration is an effective means of reducing aerosol particle concentrations. Finally, CFD simulation was used to monitor the particle fates. The steady simulation results fit quite well with the experimental findings and provide additional information about the particle path and for assessing the comfort level due to air flow.