ABSTRACT
The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.
Subject(s)
Amebicides/therapeutic use , Cryptosporidiosis/drug therapy , Cryptosporidium parvum/isolation & purification , Cyclodextrins/therapeutic use , Furans/therapeutic use , beta-Cyclodextrins , Animals , Cattle , Cryptosporidiosis/parasitology , Cryptosporidium parvum/physiology , Disease Models, Animal , Drug Carriers , Drug Therapy, Combination , Excipients , Mice , Parasite Egg CountABSTRACT
Spherical pellets containing 5% of triamcinolone acetonide (TA) were formed by extrusion/spheronization following formulation with microcrystalline cellulose (MCC) and/or a hydrophilic excipient (lactose, sodium carboxymethylcellulose or beta-cyclodextrin, beta-CD). Their suitability for coating, with a view to colonic drug delivery, was assessed in terms of their size, sphericity and dissolution test response. Best results were afforded by 5:90:5 MCC-beta-CD-TA pellets obtained by complexation of TA with beta-CD prior to addition of MCC, extrusion and spheronization.
