ABSTRACT
In trained adult albino rats, more rapid mobilization of carbohydrates and FFA, more economical carbohydrates expenditure during muscular exercise, and more rapid resynthesis of glycogen during recovery period, were observed. This depends on both the changes of 3',5'-AMP-phosphodiesterase activity of muscles, liver, and adipose tissue, and the degree of insulin inactivation by muscle and liver tissues. Both these processes considerably differ in untrained and trained animals.
Subject(s)
3',5'-Cyclic-AMP Phosphodiesterases/metabolism , Insulin/metabolism , Phosphoric Diester Hydrolases/metabolism , Physical Exertion , Adaptation, Physiological , Adipose Tissue/enzymology , Adrenal Cortex Hormones/metabolism , Animals , Fatty Acids, Nonesterified/metabolism , Glycogen/metabolism , Liver/enzymology , Liver/metabolism , Muscles/enzymology , Muscles/metabolism , Rats , Time Factors , Tissue Extracts/pharmacologyABSTRACT
In adult albino rats, increased sentivity of the organism to insulin action caused by systematic muscular exercises preserved in conditions of adrenergic blockade but was reduced by theophylline administration (inhibition of 3'-5'-AMP-phosphodiesterase activity). The sensitivity to insulin action 3'-5'-phosphodiesterase (in muscles, liver, and adipose tissue) increased during adaptation to muscular activity. Simultaneously the insulin inactivation in muscle and liver tissues also increased.
Subject(s)
Adaptation, Physiological , Insulin/pharmacology , Muscles/physiology , Physical Exertion , 3',5'-Cyclic-AMP Phosphodiesterases/metabolism , Adipose Tissue/drug effects , Adipose Tissue/metabolism , Animals , Blood Glucose/metabolism , Fatty Acids, Nonesterified/metabolism , Glycogen/metabolism , Liver/drug effects , Liver/metabolism , Liver Glycogen/metabolism , Muscles/drug effects , Muscles/metabolism , RatsABSTRACT
Systematic exercise increased the organism's sensitivity to the metabolic effect of insulin. When trained animals were subjected to low doses of insulin they showed a more significant decrease in the blood sugar and the free fatty acid contents as compared with the control (i.e. unadapted to systematic exercise) animals. No visible difference in glycogen contents was found due to the effect of hypoglycemic seizures which developed rather rapidly and were more obvious in trained animals. Administration of large doses of insulin did not cause any difference in the metabolic reactions of trained and untrained animals.
