ABSTRACT
Based on studies of certain gene-candidate polymorphism, the authors studied markers of early development and unfavorable course of pneumoconiosis in post-contact period. Analysis covered occurrence of genotypes and allels of I/D polymorphism of gene CCRS, 4a/b polymorphism of gene NOS3, VNTR polymorphism of gene ILRN, I/D polymorphism of CASP8 and mutation GLU342LYS (rs28929474) and GLU264VAL (rsl7S80) in gene SERPINAl in patients with various terms of pneumoconiosis formation. Findings are individual criteria of early formation and progress of pneumoconiosis in post-contact period..
Subject(s)
Nitric Oxide Synthase Type III/genetics , Pneumoconiosis , alpha 1-Antitrypsin/genetics , Disease Progression , Female , Gene-Environment Interaction , Humans , Male , Middle Aged , Mutation , Occupational Exposure/adverse effects , Pneumoconiosis/diagnosis , Pneumoconiosis/genetics , Pneumoconiosis/physiopathology , PrognosisABSTRACT
Analyzing distribution of genotype polymorphism occurrence of Pro l98Leu gene of GPX1 (glutathion peroxidase) and Ala 16 Val gene of MnSOD (superoxide dismutase), the authors presented major mechanisms and leading pathogenetic factors of vibration disease formation and course in post-contact period. The article covers also results of metabolic processes evaluation in patients with varying resistence to occupational vibration, for forecasting its course after discontinued contact with the factor.
Subject(s)
Glutathione Peroxidase/genetics , Hand-Arm Vibration Syndrome , Oxidative Stress , Superoxide Dismutase/genetics , Adult , Genetic Markers , Genetic Predisposition to Disease , Hand-Arm Vibration Syndrome/diagnosis , Hand-Arm Vibration Syndrome/genetics , Hand-Arm Vibration Syndrome/metabolism , Humans , Male , Middle Aged , Polymorphism, Genetic , Prognosis , Glutathione Peroxidase GPX1ABSTRACT
Obtained results of molecular genetics testing of workers' groups exposed to dust show the elimination of carriers of defective variants in the CFTR gene among workers exposed to dust. We can establish a fact that in spite of law frequency of detected major mutations of the CFTR gene in explored selections they have big importance as individual factors in the stage of preliminary medical examinations in terms of prediction of possible occupational development risk and progression of productionally mediated visceropathies and diseases, as well as a conscious choice of occupation by an individual.
Subject(s)
Air Pollutants, Occupational/adverse effects , Cystic Fibrosis Transmembrane Conductance Regulator/genetics , Dust , Lung Diseases , Occupational Diseases/genetics , Biomarkers , Gene Frequency/genetics , Genetic Predisposition to Disease , Humans , Lung Diseases/etiology , Lung Diseases/genetics , Male , Maximum Allowable Concentration , Middle Aged , Mutation/genetics , Polymorphism, Genetic/genetics , Risk Factors , Siberia/epidemiologyABSTRACT
The article covers basic mechanisms and major pathogenetic factors of pneumoconiosis formation and course in after contact period. The authors provide results of metabolic disorders analysis in the patients vairable in tolerance to industrial aerosol, to forecast pneumoconiosis course after discontinued contact with the hazard.
Subject(s)
Catalase/metabolism , Erythrocytes/metabolism , Pneumoconiosis/diagnosis , Adult , Aged , Disease Progression , Early Diagnosis , Erythrocytes/pathology , Humans , Lipid Peroxidation , Male , Middle Aged , Neutrophil Activation , Occupational Exposure/adverse effects , Oxidation-Reduction , Pneumoconiosis/pathology , Pneumoconiosis/physiopathology , PrognosisABSTRACT
The article presents results of studies concerning cardio-respiratory system, psychoemotional state and life quality in professional guttural traditional singers. The professional singers with long length of service were proved to have lower external respiratory function parameters and saturation values, polycytemic syndrome and ECG studies demonstrate reliably more frequent left ventricular hypertrophy and metabolic disorders, more considerable psychoemotional changes and life quality alterations are seen, if compared to the amateur singers.
Subject(s)
Anxiety/psychology , Cardiovascular System/physiopathology , Emotions/physiology , Music/psychology , Phonation/physiology , Quality of Life , Respiration , Anxiety/physiopathology , Blood Pressure/physiology , Electrocardiography , Heart Rate/physiology , Humans , Siberia , Voice Quality/physiologyABSTRACT
The article presents major mechanisms and leading pathogenetic factors for development and course of vibration disease in post-contact period. The authors demonstrate results of metabolic disorders assessment in patients with variable endurance to occupational vibration, for predicting vibration disease course after contact with the vactor is stopped.
Subject(s)
Antioxidants/metabolism , Lipid Peroxidation , Occupational Diseases/metabolism , Occupational Exposure/adverse effects , Vibration/adverse effects , Case-Control Studies , Catalase/metabolism , Erythrocytes/enzymology , Erythrocytes/metabolism , Humans , Lipid Peroxides/blood , Male , Middle Aged , Occupational Diseases/blood , Occupational Diseases/enzymology , Occupational Diseases/epidemiology , Occupational Diseases/etiology , Occupational Exposure/analysis , Siberia , Sulfhydryl Compounds/metabolismABSTRACT
The authors evaluated life quality of doctors and paramedics in emergency rescue service. Finding is lower life quality of this occupational category in comparison with inpatient medical personnel. The most unfavorable parameters were seen among nurses, females and individuals aged 41-50.
Subject(s)
Ambulances , Medical Staff , Quality of Life , Adult , Female , Follow-Up Studies , Humans , Male , Middle Aged , Occupational Exposure/adverse effects , Prognosis , Siberia , WorkforceABSTRACT
The article represents results of study determining biologic markers through examining phenotypic features of blood groups, blood neutrophils biocidity, lipid peroxidation and antioxidant defense in RBC. Those features result in high sensitivity or resistance to dust, in probability of early or late pneumoconiosis development.
