Patients with chronic hepatitis type C and interferon-alpha-induced hyperthyroidism in two-years clinical follow-up.

OBJECTIVES: Interferon-α (IFN-α) is a gold standard in the therapy of viral chronic hepatitis type C (CHC). However, such treatment might lead to thyroid dysfunction. Patients usually present hypothyroidism, but rarely also hyperthyroidism may develop. The aim of the study is to present two-year clinical follow-up of patients with CHC and IFN-α-induced hyperthyroidism (IIH), with special regard to the methods and efficacy of the therapy. METHODS: A group of 106 patients with CHC and IIH were analyzed. Subjects were divided into two groups according to etiology: group 1, with Graves' disease (GD) and group 2, with Hashitoxicosis (HT). The diagnosis of GD and HT was based on: clinical signs of hyperthyroidism, hormonal profile (TSH, fT4, fT3), level of thyroid autoantibodies (Tg-Abs, TPO-Abs, TSHRAbs). Treatment of hyperthyroidism was monitored by repeated clinical assessment and laboratory tests. RESULST: 28 patients (26 with GD of which 5 exhibited mild orbitopathy and 2 with HT) were treated with radioiodine [the average dose of was 17 mCi [668 MBq]. In adition 78 out of 80 patients with HT mostly ß-blocker therapy was successful (transient hyperthyroidism). At the end of the observation period, in group 1 remission was achieved in 17 (65.4%) cases, 6 (23.1%) patients showed hypothyroidism and 3 (11.5%) presented recurrence of hyperthyroidism. CONCLUSIONS: Most patients with IIH present Hashitoxicosis, while a minority of them develop Graves' disease. In a majority of patients with HT spontaneous remission of disease occurs. In patients with long-term hyperthyroidism, radioiodine therapy is an effective and well-tolerated.

Serum resistin concentrations are associated with HbA1c in obese non-diabetics, but not in obese diabetics: a cross-sectional human study.

OBJECTIVE: Glycosylated hemoglobin (HbA1c) and resistin may be influenced by diabetes, but their associations remain unclear. We hypothesized that serum resistin might be parallel to Hb1c. DESIGN AND SETTING: We measured serum resistin in 134 obese non-diabetic (73 women and 61 men), and 65 obese diabetic (33 women and 32 men) humans, and examined their relationships with HbA1c. The presence of diabetes was the only differentiating factor between the groups. RESULTS: Resistin, non-diabetic vs. diabetic, median and interquartile range, respectively: resistin (ng/mL) 26.08, 16.09 and 22.14,14.54, p>0.5. To investigate the influence of HbA1c on resistin, both groups were divided into tertiles based on HbA1c. In diabetics, resistin was similar in high, intermediate, and low HbA1c subgroups, p>0.05, and resistin was not influenced by HbA1c: r=-0.1785; p=0.15. In non-diabetics, resistin differed between HbA1c tertiles, p<0.001, and was influenced by HbA1c, r = -0.3599; p=0.0003. CONCLUSIONS: Resistin concentrations are similar in diabetic and non-diabetic humans with the same range of obesity. However, resistin is associated with HbA1c only in non-diabetic obese individuals which may point to the fact that resistin is a marker of glycaemic balance in obesity but not in diabetes.

Serum resistin is related to plasma HDL cholesterol and inversely correlated with LDL cholesterol in diabetic and obese humans.

OBJECTIVES: Plasma cholesterol, triglycerides and serum resisistin may all be influenced by diabetes and obesity, but their associations remain unclear. Therefore, we put forward a hypothesis that serum lipids might be parallel to resistin, as they all reflect the metabolic status of obese humans. DESIGN AND SETTING: We measured the concentrations of resistin, total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and triglycerides (TG) in 134 obese non-diabetic (73 women and 61 men) and 65 obese diabetic (33 women, 32 men) humans, and examined their interrelations. Obesity was defined according to the WHO criterion (BMI, ≥ 30 kg/m²) The presence of diabetes was the only differentiating factor between two groups of frankly obese humans. RESULTS: Non-diabetic vs. diabetic, median and interquartile range, respectively: resistin (ng/mL) 26.08, 16.09 vs. 22.37, 14.54, p=0.736; TC (mmol/L) 5.02, 1.39 vs. 5.16, 1.56, p=0.374; HDL-C (mmol/L): 1.10, 0.41 vs. 1.02, 0.47 p<0.05; LDL-C (mmol/L): 3.00, 1.05 vs. 3.00, 1.30 p=0.978; TG (mmol/L) 1.70, 1.43 vs.1.95, 1.81 p<0.05. To investigate the interrelations between resistin and lipids, a simple regression analysis was used, and the results were for resistin & TC, HDL-C, LDL-C, and TG, respectively: in the whole cohort r=-0.1364, p=0.0670, r=0.1514, p=0.0437, r=-0.2573, p=0.0006, r=0.0434, p=0.5597; in non-diabetics: r=-0.2067, p=0.0213, r=0.1023, p=0.2621, r=-0.2399, p=0.0083 and r=0.0288, p=0.7497; in diabetics r=0.0280, p=0.8360, r=0.2267, p=0.0929, r=-0.2933, p=0.0298, r=0.1349, p=0.3127. CONCLUSIONS: In diabetic and non-diabetic subjects the atherogenic LDL cholesterol shows an inverse correlation with resistin, whereas the protective anti-atherosclerotic HDL cholesterol is positively correlated with resistin.

Free leptin index as a marker for leptin action in diabetes and obesity: leptin and soluble leptin receptors relationship with HbA1c.

OBJECTIVES: Glycosylated haemoglobin (HbA1c), leptin, leptin soluble receptors (sOB-R) and free leptin index (FLI) may all be influenced by diabetes, but their associations remain unclear. Therefore, we put forward a hypothesis that serum leptin, sOBR and FLI might be parallel to Hb1c, as they all reflect the metabolic status. DESIGN AND SETTING: We measured leptin and sOB-R concentrations in 97 obese non-diabetic (47 women and 50 men), and 65 obese diabetic (32 women and 33 men) humans, and examined whether they were related to HbA1c. Under the condition, the presence of diabetes was the only differentiating factor between two groups of frankly obese humans. RESULTS: Non-diabetic vs. diabetic, median and interquartile range, respectively: Leptin (ng/ml), 30.83, 37.27 vs. 28.24, 23.34; p>0.05; sOB-R (ng/ml), 17.62, 17.05 vs. 21.81, 16.61, p<0.05; FLI, 231.23, 310.00 vs. 131.76, 157.68, p<0.05. To investigate the influence of HbA1c on leptin and sOB-R, both groups were divided into tertiles based on HbA1c. In diabetics, leptin did not differ between the high, intermediate, and low HbA1c levels subgroups, p>0.05, and leptin was not influenced by HbA1c levels: r=0.086; p>0.05. For sOB-R, respectively: p>0.05; r=0.080; p>0.05. In non-diabetics, respectively: p<0.05; r=0.2923; p<0.05 for leptin; and p<0.0001, r=0.5103; p<0.0001, for s-OB-R. CONCLUSIONS: Not leptin alone but serum sOB-R and FLI are the markers of leptin action impairment in type 2 diabetes. Further, HbA1c is not associated with metabolic status of leptin in obese diabetic patients, whereas this association is found in obese non-diabetic humans.

High prevalence of obesity in patients with non-functioning adrenal incidentalomas.

OBJECTIVE: The influence of obesity on cancer development has been proven for numerous tumours. In contrast, the association between obesity and non-secreting adrenal incidentaloma has never been proven. Therefore, the aim of this study was to investigate this relationship in a large sample of patients. METHODS: 143 patients with benign non-secreting adrenal incidentalomas treated in the Department of Endocrinology at the Poznan University of Medical Sciences between the years 2000-2007 were examined. To rule out subclinical hyperfunctioning lesions, serum dehydroepiandrosterone sulphate, cortisol (8 am, 6 pm, and after 1 mg dexamethasone suppression), sodium and potassium, along with concentrations of sodium, potassium, vanillylmandelic acid, metanephrine and normetanephrine in 24-hour urine collection were determined. Radiological evaluation included computed tomography and/or magnetic resonance imaging. Only non-secreting lesions and those of benign radiologic appearance were considered. The patients body mass index was compared to that of the general population of Poland and the Western Poland Region of Wielkopolska. RESULTS: The average body mass index of our patients was 28.77 kg/m2 (SD=4.71), with a 40% prevalence of obesity in the study group. One-proportion z-test showed a statistically significantly higher prevalence of obesity as compared to the general population of Poland and Wielkopolska (40% vs 12.5%, p<0.005); the results were similar for the whole cohort, and for each gender separately. CONCLUSIONS: This clinical research study demonstrates a strong association between obesity and incidentally discovered non-functioning adrenal tumours.

[Association study between exon 4 NFKBIL1 polymorphism and multiple sclerosis]. / Analiza polimorffizmu eksonu 4 NFKBIL1 w populacji chorych na stwardnienie rozsiane.

UNLABELLED: Multiple sclerosis (MS) is conceptualised as a complex autoimmune inflammatory disorder in which several environmental factors act together in a genetically susceptible individual to cause disease. Epidemiological data confirmed that genetic factors are involved in MS pathogenesis. Genes responsible for MS predisposition still await to be identified. The only consistent genetic finding, establishes so far, is the association between MS and a number of HLA haplotypes (locus 6p21.3). NFKBIL1 gene (locus 6p21.31) is one of candidate genes. One of NFKBIL1 gene coding sequence polymorphisms is a non-synonymous thymine-cytosine substitution at position 738 (exon 4) resulting in cysteine-arginine substitution at position 224 of encoded protein. THE AIM OF THE STUDY: To assess the NFKBIL 1 exon 4 contribution to MS genetic predisposition and its relationship to the clinical course of the disease. MATERIAL AND METHODS: 107 unrelated MS patients (77 female ones) attended in Department of Neurology Medical University of Poznari participated in this study. Control group included 110 healthy age and sex matched unrelated volunteers (71 female). Investigation of NFKBIL1 exon 4 polymorphism was performed with use of the single strand conformation polymorphism technique (SSCP). RESULTS: NFKBIL1 exon 4 polymorphism was observed in 10 patients and 9 control samples (9.35% and 8.18% respectively). The results remained statistically insignificant (p = 0.8136). Associations between the polymorphism and course of MS, clinical symptoms at onset, sex (p = 0.2851) and optic neuritis (ON) (p = 0.0865) were also insignificant. However, lack of statistical significance in the two latter parameters suggests insufficient size of the patients and control groups, as the absolute percentage values were remarkably different (respectively: 7.59% female vs. 14.28% male; 2.5% ON-positive vs. 13.4% ON-negative). CONCLUSIONS: The results of the present study do not provide evidence for the association between the NFKBIL1 exon 4 polymorphism and MS predisposition in the investigated Polish population. However, it may have a restricted result on MS course and a protecting effect on optic neuritis in MS patients.

Serum insulin levels and the degree of thyroid dysfunction in hypothyroid women.

OBJECTIVES: Among the peripheral effects of thyroid hormone action, their influence on insulin is of great interest and conflicting data on this subject are available. Despite various studies already performed, of concern is whether insulin levels change in line with a deterioration of thyroid function. In this study, we investigated serum serum insulin levels and their correlations with thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in hypothyroid women. DESIGN AND METHODS: Study group consisted of 22 women with a history of total thyroidectomy and radioiodine ablation performed for thyroid cancer, without diabetes or glucose intolerance. After six-weeks of thyroxine withdrawal, subjects were admitted to the Department of Endocrinology of the Poznan University of Medical Sciences to perform this study. RESULTS: Plasma glucose and insulin were respectively: 4.76+/-0.47 mmol/L and 7.19+/-4.22 microU/mL. Serum TSH, FT4 and FT3 were respectively: 91.66+/-58.59 microU/mL, 2.65+/-2.19 pmol/L, and 1.53+/-1.00 pmol/L. Correlations were: r of -0. 4381 and P of 0.0414, r of -0.2368 and P of 0.2887, and r of 0.3954 and P of 0.0686 for insulin and FT4, insulin and FT3, and insulin and TSH, respectively. The only significant correlation was an inverse correlation between insulin and FT4. CONCLUSIONS: In profound hypothyroidism insulin concentrations correlate with FT4 only, but not with FT3 or TSH.

Circulating resistin levels are lower in hypothyroid women but independent from thyroid hormones concentrations.

OBJECTIVES: Although resistin is involved in metabolism, its role in humans is unclear. Since thyroid status influences metabolism, and since only few studies have evaluated the associations between resistin and thyroid status with inconclusive results, we investigated serum serum resistin levels and their correlations with TSH, FT4 and FT3 in hypothyroid and euthyroid women. DESIGN AND METHODS: Study group consisted of 22 women with a history of total thyroidectomy and radioiodine ablation performed for thyroid cancer. Controls were 22 healthy euthyroid women matched for age and BMI. After six-weeks of thyroxine withdrawal, subjects were admitted to the Department of Endocrinology of the Poznan University of Medical Sciences to perform this study. RESULTS: Serum resistin concentrations were lower in hypothyroid patients, 12.40 +/- 5.197 vs. 18.01 +/- 7.31, p=0.0065. In hypothyroid subjects, correlations were as follows: r of -0.2636 and p of 0.248, r of 0.0336 and p of 0.885, and r of 0.3080 and P of 0.174 for resistin and FT4, resistin and FT3, and resistin and TSH, respectively. In controls: r of 0.0311 and p of 0.8908, r of -0.0986 and p of 0.6625, and r of 0.1605 and p of 0.4754 for resistin and FT4, resistin and FT3, and resistin and TSH, respectively. CONCLUSIONS: Short-term profound hypothyroidism decreased resistin levels. However, no significant correlations between the levels of circulating resistin and thyroid hormones and TSH were shown.

Serum adiponectin concentrations and their relationship with plasma lipids in obese diabetic and non-diabetic Caucasians.

OBJECTIVES: Adiponectin is a novel plasma protein produced exclusively in adipocytes. Despite early data, its relationship with obesity and diabetes has been recently questioned. Since plasma lipids influence diabetes and obesity, of concern is whether any associations between plasma lipids and adiponectin exist. DESIGN AND METHODS: The aim of this study was to measure adiponectin levels and to investigate their associations with plasma cholesterol fractions and triglycerides in 73 obese non-diabetic subjects (44 women and 29 men), and 43 obese diabetic subjects (28 women and 15 men), aged 52.7+/-11.2 and 53.1+/-11 years, respectively, and matched for age, sex and BMI. The WHO definitions of obesity and diabetes were used. Adiponectin was determined by an enzyme-linked immunosorbent assay. RESULTS: No correlations between adiponectin and total and LDL cholesterol levels were shown (for the whole cohort: r=0.0130; p=0.8899, and r=0.0807; p=0.3958, respectively). A positive correlation between HDL cholesterol levels and adiponectin occured predominantly in obese women without diabetes (r=0.4531; p=0.0023), resulting in an overall statistical trend in the whole cohort (r=0.2243; p=0.0164). A negative correlation between serum adiponectin and triglycerides was found (r=-0.3413; p=0.0002). CONCLUSION: Adiponectin correlated only with TG and partially with HDL but not with LDL and total cholesterol in the study group of obese diabetic and obese non diabetic subjects. In view of these results we suggest that the role of adiponectin in human metabolism is unclear and merits further investigation.

Circulating leptin levels are not influenced by thyroid status in hypothyroid and euthyroid women.

OBJECTIVES: Leptin regulates body weight by suppressing food intake and increasing energy expenditure. Alterations in thyroid hormone levels are also associated with changes in body weight but the effect of thyroid hormone deficiency on serum leptin in humans is unclear. DESIGN AND METHODS: The aim of this study was to measure leptin levels and to investigate their associations with thyroid hormones in 22 women with severe hypothyroidism after total thyroidectomy, and in a group of 22 healthy euthyroid control female subjects matched for age and body mass index (BMI). Their plasma leptin, free thyroxine, triiodothyronine and TSH were measured. RESULTS: Leptin levels in subjects and controls were (pg/mL) 18761.64+/-16973.96 and 18729.19+/-18014.05, respectively, p=0.9; leptin did not correlate with free thyroxine, triiodothyroinine and TSH: r=0.1039 and p=0.6453, r=0.0113 and p=0.9602, and r=-0.0525 and p=0.8165 for leptin and FT4, leptin and FT3, and leptin and TSH, respectively in subjects; r=-0.00056 and p=0.9980, r=0.248727 and p=0.2643, and r=-0.046919 and p=0.8357 for leptin and FT4, leptin and FT3, and leptin and TSH, respectively in controls. Leptin levels did not differ between subjects and controls and they did not correlate with thyroid hormones. CONCLUSIONS: Leptin levels are not influenced by hypothyroidism and do not correlate with thyroid hormones in euthyroid and hypothyroid women.

[Subclinical hypothyroidism influences ventricular repolarization measured by QTc interval]. / Subkliniczna niedoczynnosc tarczycy ma wplyw na repolaryzacje komór serca, mierzona skorygowanym odstepem QT (QTc).

UNLABELLED: Thyroid disorders exert a major effect on cardiac function and on ECG. Few studies examined the effect of thyroid hormones on ventricular repolarization, measured by corrected QT interval (QTc). Prolonged QTc is associated with increased risk of arrythmias and cardiac mortality. The aim of this study was to examine the influence of subclinical hypothyroidism on ventricular repolarization measured by corrected QTc in standard 12-lead electrocardiogram. The examined group consisted of 32 patients with hypothyroidism, the controls were 39 healthy individuals. The mean corrected QTc was 0.434, SD +/- 0.0296 seconds and 0.414, SD +/- 0.0208 in the examined groups and in controls, respectively (p < 0.01). QTc did not correlate with free thyroxine concentrations (p = 0.4064). In the group with subclinical hypothyroidism we did not observe a significant difference in heart rate (74.3 vs. 73.7, SD +/- 13.58, NS). CONCLUSION: Corrected QT intervals were significantly prolonged in patients with subclinical hypothyroidism.

[Adrenal tumours in a selected 10-years surgical material]. / Guzy nadnerczy w wybranym 10-letnim materiale operacyjnym.

UNLABELLED: The aim of the study was to analyze the number and proportions of different adrenal tumours resected during the last 10 years in our centre. Besides, we seek correlations between the size of tumours and the age and body mass indexes (BMI) of the examined patients. MATERIAL AND METHODS: The tumours where measured on CT and MRI before surgery, and on pathological examination after resection. The examined group consisted of 69 patients, 22 males and 47 females, mean age 50.51 +/- 12.26 yrs. In 45 (65.22%) cases the right adrenal was affected, in 21 (30.43%)--the left, in 3 (4.35%)--both. RESULTS: 12 adrenocortical cancers, 20 phaeochromocytomas, 9 cortisol-secreting adenomas, 4 aldosteronomas, 18 hormonally inactive adenomas, 6 miscellaneous tumours were found. Malignant tumours where significantly larger than benign (12.20 +/- 6.81 vs 6.71 +/- 5.62 cm, p < 0.005). We observed no correlation between the age and preoperative tumor size (p = 0.1756), between the age and pathological tumor size (p = 0.3601), and between BMI and the preoperative and histopathologic size (p = 0.4204, and p = 0.6478, respectively). CONCLUSIONS: The most common tumour was phaeochromocytoma. Most tumours where found in the right adrenal. The malignant tumours where larger than benign ones. No correlations between age and BMI, and tumour size where demonstrated.

[Prolonged ventricular repolarization measured by QTc interval in hyperthyroidism]. / Wydluzenie repolaryzacji komór mierzonej za pomoca odstepu QTc w przebiegu nadczynnosci tarczycy.

UNLABELLED: Thyroid dysfunction exerts an effect on cardiac function and on an electrocardiographic curve. Few studies analyzed the influence of thyroid hormones on heart repolarization. Heart repolarization is assessed in every-day-practice with corrected QT interval in ECG. Prolonged QTc is associated with increased risk for heart rythm disturbances and mortality. The aim of this study was to assess the effect of hyperthyroidism on heart repolarization, measured with QT corrected by Bazett's formula. MATERIAL AND METHODS: The study group included 68 hyperthyroid patients (30 males, 38 females, mean age 39+/-10 yrs) and the controls were 39 in age and sex matched healthy subjects. TSH and free thyroxine were assessed. The QTc was measured in a standard 12 lead ECG. RESULTS: In the study group the heart rhythm was faster when compared to controls (91.8 vs.73.7, SD+/-16.11, p<0.0001). The mean corrected QT (QTc) was 0.430, SD+/-0.0273 sec., in controls respectively: 0.414, SD+/-0.0208 sec., p<0.01. QTc did not correlate with free thyroxine concentrations (p=0.2785). CONCLUSIONS: Corrected QT intervals were significantly prolonged in hyperthyroid patients, although they did not reach high values.

[Depression and anxiety in patients with adrenal tumor incidentally found on abdominal imaging performed for other indications]. / Depresja i lek u chorych z guzem nadnercza wykrytym podczas badan prowadzonych z innych wskazan.

OBJECTIVE: The aim of this study was to assess the level of anxiety and depression in patients with non-secreting adrenal incidentaloma. MATERIAL AND METHODS: The study group comprised 26 patients (16 women, 10 men, mean age 45, SD 11 yrs). The Polish version of the State-Trait Anxiety Inventory was used to assess anxiety level, and the Beck Depression Inventory was used to measure depression symptoms. RESULTS: The anxiety level was increased (median: 45.6 for state, and 46.5 for trait), and mild depression was present, with 13.5 scores on Beck's scale. CONCLUSIONS: Adrenal incidentaloma is associated with increased anxiety and depression.

The Allan factor: a new model of mathematical interpretation of heart rate variability in stable coronary artery disease. Preliminary results.

INTRODUCTION: The current analysis of heart rate variability (HRV) is one of the noninvasive methods of cardiovascular system assessment. The quantitative characteristics of the RR interval sequence and its dynamics are still under development as regards measurement techniques and development of new HRV interpretation models. The practical clinical application of the standard measurements is still insufficient and improvement of sensitivity and specificity of HRV parameters is needed. AIM: To assess a novel mathematical model of HRV interpretation and compare it with standard HRV measurements for patients with stable coronary artery disease (CAD), based on the virtual instrumentation technique. METHODS: The study group consisted of 24 patients with CAD confirmed by coronary angiography and a control group of 15 volunteers. Short-term electrocardiographic signals were recorded by a computer system and analysed for estimation of several HRV descriptors in time, frequency and combined time-frequency domains. Calculations included standard HRV measures and the Allan factor, a parameter based on the Haar wavelet transform. RESULTS: None of the investigated measurements derived from power spectral analysis has shown a statistically significant difference between healthy controls and patients with CAD, with the exception of rMSSD (Wilcoxon test: supine position *p=0.0018, erect position p=0.0708; discriminant function analysis: supine position *p=0.0069, erect position p=0.7851). Compared with standard HRV variables, the Allan factor better discriminated patients with CAD from healthy subjects (Wilcoxon test: supine position *p=0.0172, erect position *p=0.0001; discriminant function analysis: supine position p=0.8962, erect position *p=0.0200). CONCLUSIONS: The observations related to the novel parameter based on combined time and frequency domains may provide better quantitative measurements of heart rate variability in patients with coronary artery disease and require further investigations to assess their sensitivity and specificity.

[Insulin resistance assessed with HOMA-IR in hyperthyroid patients]. / Insulinoopornosc mierzona metoda HOMA-IR u chorych na nadczynnosc tarczycy.

UNLABELLED: Hyperthyroidism may influence sensitivity to insulin. The aim of study was to assess insulin resistance in hyperthyroid patients in correlation with the plasma free thyroxine (FT4) and thyreotropin (TSH) concentrations. MATERIAL AND METHODS: The study group consisted of 15 hyperthyroid patients (11 females, 4 males, mean age 50, 6 +/- 12, 36 yrs.). The controls were 17 healthy individuals (6 females, 11 males, mean age 55, 12 +/- 14, 17 yrs.). In the study group the mean FT4 was 33.1 +/- 20.1 pmol/l, TSH 0.034 +/- 0.066 pmol/l, glucose 5.00 +/- 0.56 mmol/l, insulin 7.19 +/- 3.59 microU/mL. In the controls respectively: 16.2 +/- 1.8 pmol/l, 1.24 +/- 1.07 pmol/l, 5.04 +/- 0.62 mmol/l, 7.24 +/- 4.06 microU/mL. Insulin resistance was calculated with HOMA-IR model, and the results were in the study group: mean 1.63 +/- 0.85, range from 0.46 to 3.67, median 1.38; in the controls respectively: 1.69 +/- 1.08, range from 0.36 to 4.47, median 1.42. RESULTS: Insulin resistance did not differ significantly between the groups (p=0.8860). FT4 and TSH did not influence insulin resistance in either group, the correlations were insignificant: for FT4 and for TSH p=0.5100 and p=0.5601 in the study group, and p=0.172 and p=0.4509 in the controls, respectively. CONCLUSION: Hyperthyroidism did not influence insulin resistance assessed with HOMA-IR model in vivo.