ABSTRACT
The efficiency of therapy with the iron-containing preparation Ferro-Folgamma (Vervag Pharma, Germany) was evaluated in 62 men and women aged from 18 to 82 years with iron-deficiency anemia. Criteria for the efficiency were changes in clinical symptoms of anemia, hemoglobin level, erythrocyte and reticulocyte counts, packed cell volume, erythrocyte indices (mean erythrocyte volume, average content and concentration of hemoglobin in erythrocytes), erythropoietin level, and characteristics of iron metabolism (serum iron and ferritin levels, total iron-binding capacity of the serum, coefficient of ferritin saturation with iron), and drug tolerance. It was shown that Ferro-Folgamma is fairly well tolerated by the patients and produces good therapeutic effect when used to treat and prevent iron-deficiency anemia. Also, the study demonstrated that blood erythropoietin level being a sensitive indicator of hypoxia, it may be used as one of the most important criteria for the assessment of treatment efficiency in patients with iron-deficiency anemia.
Subject(s)
Anemia, Iron-Deficiency/drug therapy , Ferrous Compounds/therapeutic use , Administration, Oral , Adolescent , Adult , Aged , Aged, 80 and over , Anemia, Iron-Deficiency/blood , Dose-Response Relationship, Drug , Erythropoietin/blood , Female , Ferrous Compounds/administration & dosage , Follow-Up Studies , Hemoglobins/metabolism , Humans , Iron/blood , Male , Middle Aged , Treatment Outcome , Young AdultABSTRACT
The critical concentrations of the mycella formation of novobiocin, mithramycin, variamycin, erythromycin, oleandomycin and lincomycin were determined with two methods by changes in the isotherms of the surface tension and in the maximum absorption of rodamine due to the antibiotic concentrations. The results obtained with the two methods were comparable.
Subject(s)
Anti-Bacterial Agents/pharmacology , Surface-Active Agents/pharmacology , Adsorption , Dose-Response Relationship, Drug , Micelles , Rhodamines/pharmacology , Solutions , Surface TensionABSTRACT
Solubility of nystatin in dimethylsulfoxide (DMSO) and its water solutions was studied. It was found that the capacity of DMSO with respect to nystatin was at least 40 times higher than that of the known extracting agents. DMSO is recommended for extraction of nystatin from dry mycelium. The optimal conditions for extraction of nystatin and its recovery from the extract phases were determined. Nystatin isolated with this method meets the specification requirements.