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1.
Zh Vopr Neirokhir Im N N Burdenko ; 83(2): 101-108, 2019.
Article in Russian | MEDLINE | ID: mdl-31166324

ABSTRACT

Neurogenic sacral tumors are extremely rare. In most reported cases, this pathology was associated with neurofibromatosis. Sacral tumors manifest themselves at the stage when the neoplasm volume becomes giant, but these manifestations usually go unnoticed for the patient. Surgical approach to the sacral region is extremely challenging; intimate proximity of tumor capsule to vital organs, vessels, and nerves makes radical surgical treatment of these neoplasms rather difficult. A case report of radical resection of a schwannoma that was destroying the sacrum and continued to grow after radiotherapy is presented in this article.


Subject(s)
Neurilemmoma , Neurofibromatosis 1 , Spinal Neoplasms , Humans , Neurilemmoma/surgery , Neurofibromatosis 1/surgery , Sacrum , Spinal Neoplasms/surgery , Syndrome
2.
Article in English, Russian | MEDLINE | ID: mdl-25945381

ABSTRACT

Investigation of the mechanisms of radiation-induced brain injury is a relevant fundamental objective of radiobiology and neuroradiology. Damage to the healthy brain tissue is the key factor limiting the application of radiation therapy in patients with nervous systems neoplasms. Furthermore, postradiation brain injury can be clinically indiscernible from continued tumor growth and requires differential diagnosis. Thus, there exists high demand for biomarkers of radiation effects on the brain in neurosurgery and radiobiology. These markers could be used for better understanding and quantifying the effects of ionizing radiation on brain tissues, as well as for elaborating personalized therapy. Despite the high demand, biomarkers of radiation-induced brain injury have not been identified thus far. The cellular and molecular mechanisms of the effect of ionizing radiation on the brain were analyzed in this review in order to identify potential biomarkers of radiation-induced injury to nervous tissue.


Subject(s)
Biomarkers, Tumor/metabolism , Brain Injuries/diagnosis , Brain Injuries/metabolism , Brain Neoplasms/radiotherapy , Radiation Injuries/diagnosis , Radiation Injuries/metabolism , Brain Injuries/etiology , Humans
4.
Zh Vopr Neirokhir Im N N Burdenko ; (3): 37-42; discussion 42, 2009.
Article in Russian | MEDLINE | ID: mdl-20088448

ABSTRACT

Stereotactic radiosurgery (SRS) becomes more widely used in treatment of patients with intracranial tumors. In spite of low invasiveness this method produces risk of development of radiation-induced complications including symptomatic focal necrosis. Authors report a case of radiation-induced necrosis occurred in a patient treated for benign glioma using Leksell Gamma-Knife. Morphological features, risk factors, incidence, differential diagnosis and treatment of cerebral radiation-induced necroses are briefly discussed in this article.


Subject(s)
Brain Neoplasms/radiotherapy , Gamma Rays/adverse effects , Glioma/radiotherapy , Radiation Injuries/etiology , Brain Neoplasms/pathology , Brain Neoplasms/surgery , Diagnosis, Differential , Gamma Rays/therapeutic use , Glioma/pathology , Glioma/surgery , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Radiation Injuries/diagnosis , Radiation Injuries/pathology , Radiation Injuries/surgery , Radiotherapy/adverse effects , Radiotherapy/methods , Treatment Outcome
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