ABSTRACT
Data on the chemical composition of triterpenic and steroid compounds, isolated from the chaga mushroom grown in natural environment or in a synthetic culture have been summarized. Special attention has been paid to the biological activity of chaga mushroom extracts and these particular compounds against various cancer cell lines in vitro and in vivo. This analysis has demonstrated some common features in inhibition of growth of various cell lines by chaga mushroom components. In this context, the most active are triterpene compounds containing OH group at C-22 and a side chain unsaturated bond.
Subject(s)
Antineoplastic Agents/chemistry , Basidiomycota/chemistry , Steroids/chemistry , Triterpenes/chemistry , Antineoplastic Agents/pharmacology , Steroids/pharmacology , Triterpenes/pharmacologySubject(s)
Anti-Ulcer Agents/therapeutic use , Duodenal Ulcer/complications , Famotidine/therapeutic use , Histamine H2 Antagonists/therapeutic use , Peptic Ulcer Hemorrhage/prevention & control , Stomach Ulcer/complications , Adolescent , Adult , Aged , Anti-Ulcer Agents/administration & dosage , Duodenal Ulcer/drug therapy , Duodenoscopy , Famotidine/administration & dosage , Female , Gastroscopy , Histamine H2 Antagonists/administration & dosage , Humans , Male , Middle Aged , Peptic Ulcer Hemorrhage/surgery , Recurrence , Stomach Ulcer/drug therapy , Time FactorsSubject(s)
Hyperbaric Oxygenation , Kidney Failure, Chronic/etiology , Tuberculosis, Renal/therapy , Adult , Aged , Combined Modality Therapy , Glomerular Filtration Rate , Hemodynamics , Humans , Kidney Failure, Chronic/physiopathology , Kidney Failure, Chronic/therapy , Middle Aged , Tuberculosis, Renal/complications , Tuberculosis, Renal/physiopathologyABSTRACT
Studies have been made on the activity of cation- and anion-stimulated ATPases, as well as succinic dehydrogenase in homogenates and subcellular fractions from osmoregulatory organs of marine (elasmobranch and teleost) and freshwater (teleost) fishes, amphibians, reptiles, birds and mammals. The activity of Na+, K+-ATPase was found to be rather similar in almost all osmoregulatory organs of the species investigated. The highest level of Cl-stimulated ATPase was found in microsomal fraction of the kidneys from birds and mammals. Succinic dehydrogenase activity is significantly higher in the renal tissue of mammals, both in total homogenates and in mitochondrial fraction.