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[Identification of protein markers for serum diagnosis of cancer based on microRNA expression profiling].

Bukurova, Iu A; Nikitina, S L; Khankin, S L; Krasnov, G S; Lisitsin, N A; Karpov, V L; Beresten', S F.

Mol Biol (Mosk) ; 45(2): 376-81, 2011.

Article in Russian | MEDLINE | ID: mdl-21634125

ABSTRACT

A new algorithm has been developed for bioinformatics search of putative serum markers of cancer, which includes: 1) identification of microRNAs that are most often and most significantly overexpressed in tumors; 2) selection of mRNA targets regulated by microRNAs; 3) identification of mRNA targets encoding secreted proteins; 4) comparative analysis of mRNA transcription levels in normal and tumor tissues. Application of the algorithm led to discovery of seven putative serum markers of colon cancer: ADAMTS14, ANGPT2, CCL7, DEFA5, MMP11, MMP14, and PLAU. Experiments demonstrated that production of two out of seven proteins (MMP14 and DEFA5) is significantly increased in colon tumors vs. normal samples.

Subject(s)

Biomarkers, Tumor/blood , Computational Biology/methods , MicroRNAs/genetics , Neoplasms/blood , Algorithms , Biomarkers, Tumor/genetics , Databases, Genetic , Defensins/blood , Defensins/genetics , Gene Expression Profiling , Humans , Matrix Metalloproteinase 14/blood , Matrix Metalloproteinase 14/genetics , Neoplasms/diagnosis

[Orthopedic services needs]. / Potrebnost' naseleniia v ortopedicheskoi pomoshchi.

Zhuravlev, S M; Kuz'menko, I M; Nikitina, S L.

Sov Zdravookhr ; (5): 32-6, 1984.

Article in Russian | MEDLINE | ID: mdl-6237422

Subject(s)

Health Services Needs and Demand , Health Services Research , Orthopedics , Adolescent , Adult , Aged , Bone Diseases/epidemiology , Child , Child, Preschool , Female , Humans , Infant , Joint Diseases/epidemiology , Male , Middle Aged , Moscow , Rural Population , Russia , Urban Population

[Orthopedic morbidity and normal requirements for specialized care of the adult population of a large city]. / Ortopedicheskaia zabolevaemost' i normativy potrebnosti v spetsializirovannoi pomoshchi vzroslogo naseleniia krupnogo goroda.

Zhuravlev, S M; Liuboshits, N A; Kuz'menko, I M; Nikitina, S L.

Ortop Travmatol Protez ; (11): 56-61, 1983 Nov.

Article in Russian | MEDLINE | ID: mdl-6657224

Subject(s)

Bone Diseases/epidemiology , Health Services Needs and Demand , Health Services Research , Joint Diseases/epidemiology , Orthopedics , Adolescent , Adult , Female , Humans , Male , Middle Aged , Moscow , Urban Population

[Orthopedic morbidity in children in big city]. / Izuchenie ortopedicheskoi zabolevaemosti u detei v usloviiakh krupnogo goroda.

Zhuravlev, S M; Liuboshits, N A; Nikitina, S L; Kuz'menko, I M.

Ortop Travmatol Protez ; (3): 43-7, 1983 Mar.

Article in Russian | MEDLINE | ID: mdl-6866469

Subject(s)

Joint Diseases/epidemiology , Orthopedics , Spinal Diseases/epidemiology , Adolescent , Child , Child, Preschool , Female , Flatfoot/epidemiology , Hip Dislocation, Congenital/epidemiology , Humans , Infant , Male , Moscow

[Isolated bone abscesses in children and their treatment]. / Izolirovannye abstsessy kosti u detei i ikh lechenie.

Nikitina, S L.

Ortop Travmatol Protez ; 34(5): 40-4, 1973 May.

Article in Russian | MEDLINE | ID: mdl-4770472

Subject(s)

Abscess/therapy , Bone Diseases/therapy , Abscess/drug therapy , Abscess/surgery , Adolescent , Bone Diseases/drug therapy , Bone Diseases/surgery , Child , Child, Preschool , Extremities , Humans , Lincomycin/therapeutic use

[Results of studying indices of immunologic reactivity following bone homotransplantation. II]. / O rezul'tatakh izucheniia nekotorykh pokazatelei immunologicheskoi reaktivnosti bol'nykh posle gomotransplantatsii kosti. I.

Govallo, V I; Volkov, M V; Kopelian, I I; Grigor'eva, M P; Nikitina, S L.

Ortop Travmatol Protez ; 33(11): 6-10, 1972 Nov.

Article in Russian | MEDLINE | ID: mdl-4581856

Subject(s)

Bone Transplantation , Lymphocyte Activation , Transplantation Immunology , Bone and Bones/immunology , Histocompatibility Antigens , Histocompatibility Testing , Humans , Transplantation, Homologous , Ultrasonic Therapy

[Post-traumatic ossification of the elbow joint in children]. / Posttravmaticheskie ossifikaty lokevogo sustava u detei.

Nikitina, S L.

Ortop Travmatol Protez ; 33(4): 51-3, 1972 Apr.

Article in Russian | MEDLINE | ID: mdl-5019674

Subject(s)

Elbow Injuries , Elbow Joint , Child , Humans , Osteogenesis

[Use of Volkov's splint in the functional treatment of congenital dislocation of the hip in children]. / Primenenie zhiny volkova pri funktsional'nom lechenii vrozhdennogo vyvikha bedra u detei.

Morozova, A A; Nikitina, S L.

Ortop Travmatol Protez ; 31(7): 79-82, 1970 Jul.

Article in Russian | MEDLINE | ID: mdl-5479562

Subject(s)

Hip Dislocation, Congenital/therapy , Splints , Child, Preschool , Humans , Infant

[Isolated abscess of the bone in children]. / Izolirovannye abstsessy kosti u detei.

Volkov, M V; Nikitina, S L.

Khirurgiia (Mosk) ; 46(7): 68-73, 1970 Jul.

Article in Russian | MEDLINE | ID: mdl-5471087

Subject(s)

Bone Diseases , Abscess , Adolescent , Child , Child, Preschool , Humans , Suppuration

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