Condition of the Right Heart in Patients With COVID-19­Associated Pneumonia: Follow-Up During Hospitalization.

Aim      Dynamic assessment of the right heart in patients with COVID-19-associated pneumonia of different severity during regression of the systemic inflammatory response (SIR).Material an methods    This single-center prospective study included 46 patients with the novel coronavirus infection COVID-19 and viral pneumonia according to chest multispiral computed tomography (CT). Laboratory and echocardiographic examinations of patients were performed.Results Based on the results of evaluation with the Clinical Condition Scale (CCS-COVID), patients were divided into two groups: group A, patients with a score from 6 to 9 and group B, patients with a score from 10 to 14. The study results of both groups were evaluated twice: on day 10±2.5 from the onset of symptoms (groups A10 and B10, respectively) and again on day 17±1.8 (groups A17 and B17, respectively). Patients of group B10 had more pronounced SIR (C-reactive protein, 111.38±52.5 mg / l) and a larger volume of ground-glass opacity (38.3±9.6 %). At the first stage, higher values of right ventricular global longitudinal strain (RV GLS) were detected in group B10 compared to group A10 (23.2±4.8 % vs. 19.9±3.5 %, р=0.048). During the regression of SIR intensity and the positive dynamics of CT, lower values of Е / А were observed in group B17 (1.0 [0.98; 1.2]) vs. group А17 (1.4 [1.18; 1.5, p=0.015), and е' / a' in group B17 (0.66 [0.58; 0.85]) vs. 0.95 [0.79; 1.12] in group B17 (p=0.010). Е / А and е' / a' ratios were correlated with total lactate dehydrogenase fraction (r= -0.452 and p=0.006; r= -0.334 and p=0.050, respectively).Conclusion      In patients with severe COVID-19-associated pneumonia during regression of SIR intensity, changes in the parameters that reflected RV diastolic dysfunction were observed.

[Determination of the absorption capacity of peripheral blood neutrophils and monocytes]. / Opredelenie poglotitel'noi sposobnosti neitrofilov i monotsitov perifericheskoi krovi.

The absorption capacity of peripheral blood neutrophils and monocytes has been studied in 32 donors using color (red) latex made in Russia. The method is simple, cheap, and provides good quantitative and reproducible results.

[The Technicon H-1 automatic blood analyzer in the hematology clinic]. / Avtomaticheskii analizator krovi "Tekhnikon H-1" v gematologicheskoi klinike.

Technicon H-1, an automated flow blood analyzer with determination of the leukocytic formula of cellular peroxidase activity for differentiated estimation, is used at the laboratory of N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences. Analysis of the incidence of changes in the basic and additional characteristics recorded by the device in analyses of peripheral blood from 76 hematological patients, mainly with hemoblastosis variants, showed that if the number of blast cells were up to 45%, the analyzer recorded from 3 to 7 additional "alarm" signals, and a "blast+" signal in approximately 52% of these; if the count of blast cells were over 45%, the signal "blast+" was shown by the analyzer in 100% cases. A peroxidase channel helps detect the lymphoid or myeloid trend of leukemic cell differentiation.