ABSTRACT
AIM: To study activity of angiotensin converting enzyme (ACE) in blood serum of patients with stable effort angina. MATERIAL AND METHODS: ACE activity was measured in 11 patients (age 35-45, mean 46.5+/-1.6 years) with typical class II-III effort angina without hypertension or contractile insufficiency of the myocardium previously not treated with ACE inhibitors. Diagnosis was verified by angiography (7 patients), data of 24 hour ECG monitoring and exercise tests. Control group comprised 13 practically healthy subjects (age 36-54, mean 48.3+/-2.09 years). RESULTS: ACE activity in controls was 32.5-57 micromol/min/l (mean 46.2+/-2.0 micromol/min/l), in patients -- 48-110 micromol/min/l (mean 73.5+/-5.9 micromol/min/l), p<0.001. More than 2/3 of patients (7 of 11) had ACE activity above upper limit of norm.
Subject(s)
Angina Pectoris/enzymology , Angina Pectoris/physiopathology , Peptidyl-Dipeptidase A/blood , Physical Exertion , Adult , Angina Pectoris/diagnosis , Coronary Angiography , Female , Humans , Male , Middle AgedABSTRACT
The efficacy of examination of various cytologic material in patients with mesothelioma was analysed. A total of 48 studies were carried out in 24 patients. Examination of transthoracic aspiration material obtained from the tumor and pleural cavity exudate yielded the best results. When mesothelioma of the pleura is suspected, care should be taken to collect material from different areas of the tumor, bearing in mind the significance of discovering different components of the tumor in it. On grounds of study of various cytologic material, a malignant tumor or adenocarcinoma was diagnosed in 43% and mesothelioma in 48% of patients.
Subject(s)
Mesothelioma/pathology , Pleural Effusion/pathology , Pleural Neoplasms/pathology , Adult , Aged , Female , Humans , Male , Mesothelioma/epidemiology , Middle Aged , Pleural Neoplasms/epidemiology , Retrospective Studies , Russia/epidemiologyABSTRACT
In a series of 30,000 cytologic examinations carried out in patients with lung pathology, 20 results were considered false-positive for cancer. However, in 5 of them, malignancy was subsequently confirmed. These data were analysed to identify patterns of lung cancer in which cytologic samples are likely to be misinterpreted as false-positive.
