[The relationship of the therapeutic efficacy of immunoglobulin against tick-borne encephalitis to the specific activity of the preparation and the times of its administration]. / Sviaz' lechebnoi éffektivnosti immunoglobulina protiv kleshchevogo éntsefalita so spetsificheskoi aktivnost'iu preparata i srokami ego vvedeniia.

A controlled clinical trial included 115 patients with meningeal and focal tick-borne encephalitis, 38 of them received nonspecific treatment alone, 77 were given adjuvant intramuscular immunoglobulin against tick-borne encephalitis. The latter are shown to improve much more rapidly than patients treated only symptomatically. When calculating adequate immunoglobulin doses, it is necessary to take in consideration not only the amount of the compound, but also the concentration of the specific antibodies. The authors propose treatment schemes for patients with meningeal and focal tick-borne encephalitis.

[The transmission of the tick-borne encephalitis virus via cow's milk]. / O peredache virusa kleshchevogo éntsefalita s korov'im molokom.

A case of group infection with tick-borne encephalitis (TBE) in Bikin, Khabarovsk Territory is reviewed. The disease developed as a result of drinking raw cow milk, bought from one owner, and eating sour-milk products made of that milk. 5 persons from 3 families were ill, in three cases the outcome was lethal. Data of clinical, epidemiological, viral and serological examinations confirm the diagnosis of TBE. Various antibodies to TBE virus have been determined in the blood of cows. The presence of complement-fixing antibodies may indicate fresh infection. The characteristics of TBE viral strain, isolated from the brain of dead Z. N. F. is presented on white mice. The data obtained confirm the previous suggestion on possible transmission of TBE virus with cow milk.

[Tick-borne encephalitis in a northern zone of coniferous and broad-leaved forests of a focal region of the Amur River basin]. / Kleshchevoi éntsefalit na severe zony khvoino-shirokolistvennykh lesov ochagovogo regiona Priamur'ia.

The geographical variability of the population of tick-borne encephalitis (TBE) virus in the northern part of the zone of combined coniferous and broad-leaved forests was established; this variability was manifested by higher virulence and homogeneity of TBE virus strains, as shown in experiments on white mice receiving the virus extraneurally, in comparison with the southern part of the zone and by higher virus carriership of the ticks Ixodes persulcatus. With the epizootic situation remaining tense and the danger of TBE virus infection still present, TBE morbidity and mortality rates decreased in the years of the construction of the Baikal-Amur Railroad, which was due to greater attention given to measures for the prophylaxis of TBE during this period.

[Detection of the natural heterogeneity of natural populations of tick-borne encephalitis viruses and a grouping of the strains]. / Vyiavlenie estestvennoi neodnorodnosti prirodnykh populiatsii virusa kleshchevogo éntsefalita i gruppirovka shtammov.

Eighty strains of tick-borne encephalitis virus isolated from I. persulcatus ticks collected in 1976-1981 in the same biotopes in the south and north of the zone of coniferous-broad-leaved forests, and two biotopes of the southern taiga subzone of the Khabarovsk region and Sakhalin island, as well as from the brains of fatal cases were studied. Significant differences were found between maximal and minimal values of the invasive activity in spatially separated populations of the same zone (t = 2.32, P less than 0.02). Significant interpopulation differences were also found in the value of peripheral activity (t = = 2.77, P less than 0.02) and invasivity index (t = 3.83, P less than 0.01). Natural heterogeneity of the strains was found both by previously known markers (high neurovirulence for mice, invasivity index, plaque size in SPEV cell culture, viremia in mice, stability to thiamine 10X- and a new marker proposed by us: the degree of adsorption of hemagglutinins on an ion-exchanger DEAE-Sephadex A-50. Strains of tick-borne encephalitis virus were grouped in two landscape zones, this grouping indicated the existence of significant interpopulation differences.

[Clinico-virologic analysis of the incidence of tick-borne encephalitis in the Khabarovskh region]. / Kliniko-virusologicheskii analiz zabolevaemosti kleshchevym éntsefalitom v Khabarovskom krae.

In the Soviet Union the incidence of tick-borne encephalitis is the highest in the geographical and epidemiological region adjacent to the Amur River (zone of coniferous and broad-leaved forests). 60.43% of all cases fall on years of cyclic rise of the disease incidence. Strains of the tick-borne encephalitis virus can be isolated with a more significant frequency from the blood of encephalitis-sick patients and from the brain of the dead in the years of disease outbreaks.

[Effect of the properties of tick-borne encephalitis virus strains ciruclating in nature on the immunity of the Priamurian population]. / O vliianii svoistv shtammov virusa kleshchevogo éntsefalita, tsirkuliruiushch tsirkuliruiushchikh v prirode, na immunitet u naseleniia Priamur'ia

Strains of tick-borne encephalitis virus isolated from I. persulcatus ticks collected in various landscape zones of Priamurie differ in their invasiveness and hemagglutinating activity. A relationship between these properties of tick-borne encephalitis virus strains and the percentage of immune subjects in the population has been established. The coefficient of the epidemic danger of a landscape zone is described which includes the index of probability of infection and characteristics of the index of strain invasiveness and permits prognosis of the nature of the epidemic process in the area.