Capparis zeylanica L. conjugated TiO2 nanoparticles as bio-enhancers for antimicrobial and chronic wound repair.

Chronic, non-healable wounds have been a threat throughout history and have consumed centuries of traditional and modern research. In wound repair, a growing variety of novel treatments have been developed. At various stages of wound healing, nanostructure systems are employed. The drug may be synthesized at the nanoscale to act as a "provider," or nanomaterial could be employed as biomedical devices. Capparis zeylanica was used to synthesize Titanium dioxide nanoparticles (TiO2NPs) under ambient temperature. The UV-Vis spectrophotometer was used to confirm the illumination of fabricated TiO2NPs tuned to a size of 352 nm TiO2NPs have been revealed to be spherical and linked to one another using scanning electron microscopy. Biologically active functionality molecules involved in green synthesized TiO2NPs were indicated by Fourier transform infrared spectroscopy peaks. The TiO2NPs are amorphous, according to X-ray diffraction spectra. Skin diseases causing pathogens were studied for anti-microbial activity using the agar well diffusion method, and the results indicated significant anti-microbial properties. Furthermore, the wound healing ability of fabricated TiO2NPs was investigated in an excision wound model in Swiss albino mice. Finally, our findings revealed that TiO2NPs had provided a unique therapeutic approach for wound healing and in the planning of therapies.

TiO2 nanoparticles derived from egg shell waste: Eco synthesis, characterization, biological and photocatalytic applications.

Biosynthesis of metal oxide nanoparticles has attracted much attention in recent years owing to the increasing impact for improving hygienic substances, cost effective approaches, environment friendly solvents and reusable resources. The present study has shown the eco synthesis of TiO2 nanoparticles using the aqueous extract of egg shell waste. UV, XRD, FT-IR, and FE-SEM with EDX methods were implied for TiO2 nanoparticles. The agar well approach was used to investigate the antimicrobial properties of biosynthesized nanoparticles against pathogenic organisms. The cytotoxicity analysis was investigated by MTT assay method and photocatalytic activity was studied using methylene blue, methyl orange and Congo red dye. X-ray diffraction studies showed that the presence of tetragonal structure. The crystallite size of synthesized TiO2 nanoparticles is 27.3 nm. FE-SEM analysis indicates that the average grain size of the prepared sample was found to be in the range of 30-40 nm. Eco synthesis of TiO2 nanoparticles displayed amazing antimicrobial efficacies against human pathogenic organisms and obtained excellent cytotoxicity investigation was performed against Osteosarcoma cell lines (MG-63). Further it was also found that the expression of impressive catalytic efficiency, 91.1 percent decreased in 60 min for methylene blue. From the results, we found that eco synthesized TiO2 nanoparticles has promising utility in multidisciplinary like antimicrobial, anticancer and photocatalytic applications.