Temporal and spatial characteristics of high temperatures, heat waves, and population distribution risk in China from 1951 to 2019.

Understanding the relationships between high temperatures (HT) and heat waves (HW) is vital for enhancing human health, especially in areas with dense population. This paper analyzes the temporal and spatial characteristics of different HT and HW intensities, their spatial influence, and the population distribution risk at different HW intensities for 844 meteorological stations between 1951 and 2019. The results indicate that (1) HT and extreme temperature (ET) days are symmetrically distributed along the Huhuanyong Line, from southeast to northwest China. The times, days, and accumulated temperatures of HW, the times, days, and accumulated temperature of strong heat waves (SHW), and the times, days, and accumulated temperature of extreme heat waves (EHW) were distributed similarly; (2) with the increase in high temperatures or heat waves from HT to ET or from HW to SHW, the proportion of stations with an upward trend was always greater in China, while stations with a downward trend were mainly located in the North China Plain and Huai River Basin. For HW, SHW, and EHW, the increasing range of times and days were less than the accumulated temperatures; (3) between 1990 and 2019, there was an expansion of the HW and SHW distribution area with an annual average of more than 10 days, and the EHW distribution area with an annual average of more than 3 days. Moreover, the number of people exposed to HW, SHW, and EHW also increased during this period; and (4) considering the population distribution characteristics and the regional HT and HW characteristics, society needs to form regional adaptation actions for different HT and HW intensities.

Dynamics of estrogen-induced ROS and DNA strand break generation in estrogen receptor α-positive breast cancer.

DNA repair machinery is involved in estrogen-dependent transactivation. Mounting evidence suggests that mechanisms underlying estrogen-induced DNA damage are complicated. To date estrogen-induced DNA oxidation and its impact on ERα-mediated transaction remains ambiguous. Herein, we found that the process of 17ß-estradiol (E2)-induced ROS production can be approximately divided into two phases according to responding time and generation mechanisms. The intracellular Ca2+ fluctuation and ERα-dependent transcription lead to temporospatially different oxidative DNA damage. Further, we demonstrate that DNA oxidation is dispensable for estrogen-responsive gene expression. Dynamics of estrogen-induced DNA strand break generation also show two-phase pattern and topoisomerase-mediated DNA stand breaks are essential in estrogen signaling. Collectively, our findings have provided new insights into oxidative DNA damage in estrogen signaling.

Spatial-Temporal Characteristics in Grain Production and Its Influencing Factors in the Huang-Huai-Hai Plain from 1995 to 2018.

The Huang-Huai-Hai Plain is the major crop-producing region in China. Based on the climate and socio-economic data from 1995 to 2018, we analyzed the spatial-temporal characteristics in grain production and its influencing factors by using exploratory spatial data analysis, a gravity center model, a spatial panel data model, and a geographically weighted regression model. The results indicated the following: (1) The grain production of eastern and southern areas was higher, while that of western and northern areas was lower; (2) The grain production center in the Huang-Huai-Hai Plain shifted from the southeast to northwest in Tai'an, and was distributed stably at the border between Jining and Tai'an; (3) The global spatial autocorrelation experienced a changing process of "decline-growth-decline", and the area of hot and cold spots was gradually reduced and stabilized, which indicated that the polarization of grain production in local areas gradually weakened and the spatial difference gradually decreased in the Huang-Huai-Hai Plain; (4) The impact of socio-economic factors has been continuously enhanced while the role of climate factors in grain production has been gradually weakened. The ratio of the effective irrigated area, the amount of fertilizer applied per unit sown area, and the average per capita annual income of rural residents were conducive to the increase in grain production in the Huang-Huai-Hai Plain; however, the effect of the annual precipitation on grain production has become weaker. More importantly, the association between the three factors and grain production was found to be spatially heterogeneous at the local geographic level.