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1.
Nano Lett ; 24(1): 165-171, 2024 Jan 10.
Article in English | MEDLINE | ID: mdl-38010996

ABSTRACT

The inherent zero-band gap nature of graphene and its fast photocarrier recombination rate result in poor optical gain and responsivity when graphene is used as the light absorption medium in photodetectors. Here, semiconducting graphene nanoribbons with a direct bandgap of 1.8 eV are synthesized and employed to construct a vertical heterojunction photodetector. At a bias voltage of -5 V, the photodetector exhibits a responsivity of 1052 A/W, outperforming previous graphene-based heterojunction photodetectors by several orders of magnitude. The achieved detectivity of 3.13 × 1013 Jones and response time of 310 µs are also among the best values for graphene-based heterojunction photodetectors reported until date. Furthermore, even under zero bias, the photodetector demonstrates a high responsivity and detectivity of 1.04 A/W and 2.45 × 1012 Jones, respectively. The work shows a great potential of graphene nanoribbon-based photodetection technology.

2.
Dis Markers ; 2022: 2056837, 2022.
Article in English | MEDLINE | ID: mdl-35578691

ABSTRACT

Identifying an epidermal growth factor receptor (EGFR) mutation is important because EGFR tyrosine kinase inhibitors are the first-line treatment of choice for patients with EGFR mutation-positive lung adenocarcinomas (LUAC). This study is aimed at developing and validating a radiomics-based machine learning (ML) approach to identify EGFR mutations in patients with LUAC. We retrospectively collected data from 201 patients with positive EGFR mutation LUAC (140 in the training cohort and 61 in the validation cohort). We extracted 1316 radiomics features from preprocessed CT images and selected 14 radiomics features and 1 clinical feature which were most relevant to mutations through filter method. Subsequently, we built models using 7 ML approaches and established the receiver operating characteristic (ROC) curve to assess the discriminating performance of these models. In terms of predicting EGFR mutation, the model derived from radiomics features and combined models (radiomics features and relevant clinical factors) had an AUC of 0.79 (95% confidence interval (CI): 0.77-0.82), 0.86 (0.87-0.88), respectively. Our study offers a radiomics-based ML model using filter methods to detect the EGFR mutation in patients with LUAC. This convenient and low-cost method may be of help to noninvasively identify patients before obtaining tumor sample for molecule testing.


Subject(s)
Adenocarcinoma of Lung , Lung Neoplasms , Adenocarcinoma of Lung/diagnostic imaging , Adenocarcinoma of Lung/genetics , ErbB Receptors/genetics , Humans , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/genetics , Machine Learning , Mutation , Retrospective Studies
3.
PLoS One ; 16(5): e0250613, 2021.
Article in English | MEDLINE | ID: mdl-33961638

ABSTRACT

Global navigation satellite system (GNSS) is a well-established sensors in the recent ionosphere research. By comparing with classical meteorological equipments, the GNSS application can obtain more reliable and precious ionospheric total electron content (TEC) result. However, the most used GNSS ionospheric tomography technique is sensitive to a priori information due to the sparse and non-uniform distribution of GNSS stations. In this paper, we propose an improved method based on adaptive Laplacian smoothing and algebraic reconstruction technique (ALS-ART). Compared with traditional constant constraints, this method is less dependent on a priori information and adaptive smoothing constraints is closer to the actual situation. Tomography experiments using simulated data show that reconstruction accuracy of ionospheric electron density using ALS-ART method is significantly improved. We also use the method to do the analysis of real observation data and compare the tomography results with ionosonde observation data. The results demonstrate the superiority and reliability of the proposed method compared to traditional constant constraints method which will further improve the capability of obtaining precious ionosphere TEC by using GNSS.


Subject(s)
Air Ionization , Algorithms , Atmosphere , Geographic Information Systems/instrumentation , Image Enhancement/methods , Models, Theoretical , Reproducibility of Results
4.
Nat Commun ; 12(1): 1207, 2021 Feb 22.
Article in English | MEDLINE | ID: mdl-33619284

ABSTRACT

In Earth's low atmosphere, hurricanes are destructive due to their great size, strong spiral winds with shears, and intense rain/precipitation. However, disturbances resembling hurricanes have not been detected in Earth's upper atmosphere. Here, we report a long-lasting space hurricane in the polar ionosphere and magnetosphere during low solar and otherwise low geomagnetic activity. This hurricane shows strong circular horizontal plasma flow with shears, a nearly zero-flow center, and a coincident cyclone-shaped aurora caused by strong electron precipitation associated with intense upward magnetic field-aligned currents. Near the center, precipitating electrons were substantially accelerated to ~10 keV. The hurricane imparted large energy and momentum deposition into the ionosphere despite otherwise extremely quiet conditions. The observations and simulations reveal that the space hurricane is generated by steady high-latitude lobe magnetic reconnection and current continuity during a several hour period of northward interplanetary magnetic field and very low solar wind density and speed.

5.
ACS Omega ; 5(6): 3000-3005, 2020 Feb 18.
Article in English | MEDLINE | ID: mdl-32095723

ABSTRACT

In this work, we propose using periodic Au nanoparticles (NPs) in indium selenide-based optoelectronic devices to tune the optical absorption of indium selenide. Electromagnetic simulations show that optical absorption of indium selenide can be manipulated by tuning plasmonic resonance. The effect on the plasmonic resonance of the size, period of NPs, the thickness of silicon oxide, and the insulator spacer is systematically analyzed. A high absorption enhancement over the visible spectrum is achieved through systematic optimization of nanostructures.

6.
Sensors (Basel) ; 16(8)2016 Aug 08.
Article in English | MEDLINE | ID: mdl-27509503

ABSTRACT

The Beidou navigation satellite system is a very important sensor for positioning in the Asia-Pacific region. The Beidou inclined geosynchronous orbit (IGSO) and medium Earth orbit (MEO) satellites have been analysed in some studies previously conducted by other researchers; this paper seeks to gain more insight regarding the geostationary earth orbit (GEO) satellites. Employing correlation analysis, Fourier transformation and wavelet decomposition, we validate whether there is a systematic bias in their multipath combinations. These biases can be observed clearly in satellites C01, C02 and C04 and have a great correlation with time series instead of elevation, being significantly different from those of the Beidou IGSO and MEO satellites. We propose a correction model to mitigate this bias based on its daily periodicity characteristic. After the model has been applied, the performance of the positioning estimations of the eight stations distributed in the Asia-Pacific region is evaluated and compared. The results show that residuals of multipath series behaves random noise; for the single point positioning (SPP) and precise point positioning (PPP) approaches, the positioning accuracy in the upward direction can be improved by 8 cm and 6 mm, respectively, and by 2 cm and 4 mm, respectively, for the horizontal component.

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