ABSTRACT
Four homoisoflavonoids, 4-O-methylsappanol (1), protosappanin A (2), brazilin (3) and caeasalpin J (4), isolated from Caesalpinia sappan, were tested for inhibitory activity against Beauveria bassiana. Compound 1 showed activity against this fungus.
Subject(s)
Antifungal Agents/pharmacology , Fabaceae , Isoflavones/pharmacology , Mitosporic Fungi/drug effects , Phytotherapy , Plant Extracts/pharmacology , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Humans , Isoflavones/administration & dosage , Isoflavones/therapeutic use , Microbial Sensitivity Tests , Plant Extracts/administration & dosage , Plant Extracts/therapeutic useABSTRACT
The latex of Euphorbia nivulia afforded two ingol diterpenes 3,12-diacetyl-8-benzoylingol (4) and 3,12-diacetyl-7-benzoyl-8-nicotinylingol (5) along with three known ingol diterpenes 1, 2,and 3, and two known triterpenes cycloart-25-en-3beta-ol and cyclonivulinol. Their structures have been assigned on the basis of their structural data as well as their acetylated products. The diterpenes 1-5 were tested for the LPS induced PGE(2) inhibition activity.
Subject(s)
Diterpenes/isolation & purification , Euphorbia/chemistry , Dinoprostone/antagonists & inhibitors , Diterpenes/chemistry , Diterpenes/pharmacology , Humans , Magnetic Resonance Spectroscopy , Triterpenes/chemistry , Triterpenes/isolation & purificationABSTRACT
An immunosuppressive, tryptophan-derived alkaloid cristatin A (1), and two known compounds, cycloartenol and stigmasta-5,11(12)-diene-3 beta-ol, were isolated from the whole plant Lepidagathis cristata Willd. The structures of the isolates were established by interpretation of their spectral data.
