ABSTRACT
Synthesis of an azanucleoside, a new analogue of dideoxyadenosine, is described. This compound is only slowly deaminated by mammalian adenosine deaminase and it is a substrate for adenosine kinase. It exhibits in vitro anti-HIV activity.
Subject(s)
Anti-HIV Agents/chemical synthesis , Anti-HIV Agents/pharmacology , Deoxyadenosines/chemical synthesis , Deoxyadenosines/pharmacology , Anti-HIV Agents/chemistry , Cell Line , Chromatography, High Pressure Liquid , Deoxyadenosines/chemistry , HIV-1/drug effects , Humans , Kinetics , Magnetic Resonance Spectroscopy , Mass Spectrometry , Molecular Structure , Spectrophotometry, UltravioletABSTRACT
A detailed chemical analysis of the non-volatile secondary metabolites of Encyclia longifolia Schltr. syn. Epidendrum longifolium Barb. Rodr. was carried out in an attempt to lend a chemotaxonomic support for the recent separation of the genus Encyclia into Encyclia Hook and Prosthechea Knowles & Westc.
Uma análise química detalhada dos metabólitos secundários não voláteis de Encyclia longifolia Schltr. Sin. Epidendrum longifolium Barb. Rodr. foi realizada na tentativa de prestar suporte quimiotaxonômico para a recente separação do gênero Encyclia em Encyclia Hook e Prosthechea Knowles & Westc.
