Initial experience in assessing diagnostic utility of conventional and functional imaging (staging CT, PET CT, and MRI Brain/Spine) in suspected cases of paraneoplastic neurological syndrome.

Objectives: Radiology receives a large volume of referrals for systemic scans and neuroimaging in suspected cases of paraneoplastic neurological syndrome (PNS) patients. To date, there have been no guidelines to define imaging pathways in diagnosis or surveillance of such patients. This article aims to evaluate diagnostic utility of imaging in detecting positive results as well as ruling out significant pathologies in suspected cases of PNS and strategize vetting requests. Materials and Methods: Retrospectively evaluated scan records, onconeuronal antibody results of 80 patients (separated into below and over 60s age group) referred with suspected PNS (categorized as classical or probable PNS after neurological assessment). Imaging findings and final diagnoses were classified into three groups: Normal (N), non-neoplastic significant findings (S), and malignancies (M) after evaluating histopathology results/ perioperative findings and treatment notes. Results: There were ten cases of biopsy-proven malignancies and 18 cases of non-neoplastic significant conditions (predominantly neurological) with malignancies dominating in the elderly age group, demyelinating neurological conditions in below 60s group and patients suspected of classical PNS on neurological evaluation. Staging computed tomography (CT) had 50%, positron emission tomography CT (PETCT) had 80%, sensitivity had 93%, and negative predictive value in ruling out malignancy had 96%. Magnetic resonance of brain and spine was reported abnormal in 68% of finally diagnosed positive cases while only 11% cases demonstrated onconeuronal antibody positivity. Conclusion: Complete neuroimaging before systemic scans, categorization of referral requests in probable and classical cases of PNS with prioritization of PET in cases of high clinical concern might help in better detection of pathologies and reduce unnecessary CTs.

Imaging Tips and Tricks in Management of Renal and Urothelial Malignancies.

Management of urological malignancies has evolved significantly with continually changing guidelines and treatment options which demand more centralized involvement of radiology than ever before. Radiologists play a pivotal role in interpreting complex cancer scans and guiding clinical teams toward the best management options in the light of clinical profile. Management of complex uro-oncology cases is often discussed in multidisciplinary meetings which are essential checkpoints to evaluate an overall picture and formulate optimal treatment plans. The aim of this article is to provide a radiological perspective with practical guidance to fellow radiologists participating in uro-oncology multidisciplinary meetings based on commonly encountered case scenarios, updated guidelines, and cancer pathways. Crucial imaging tips with regards to renal and urinary tract cancers, upon which therapeutic decisions are made, have been condensed in this article after reviewing several complex cases from urology multidisciplinary meetings and European Association of Urology guidelines. Outline of various diagnostic and management strategies, key staging features, surveillance guidelines, and, above all, what the onco-urologists want to know from radiologists have been succinctly discussed in this article.

Spectrum of imaging manifestations of tumour recurrences in orthotopic neobladder.

Continent diversion with orthotopic neobladder is the most upcoming form of urinary diversion postradical cystectomy. This allows patients to void through the native urethra preserving the maximal quality of life. These patients with greater life expectancies increasingly present with a wide range of late complications, which also include local recurrences involving neobladder. Such presentations on surveillance scans can be challenging for radiologists unfamiliar with expected post-surgical anatomy and usual sites of local recurrences. Tumour in neobladder, although rare, has predilection concerning specific sites of involvement and few distinct histological types. Major subtypes of such recurrences with corresponding radiological features on multimodality imaging have been discussed in this article. Management of such cases with revision of diversions is challenging, and surgeons expect a meticulous read of such scans before contemplating pelvic clearance and secondary diversions. This pictorial review aims to appraise the literature related to various primary and secondary types of tumours involving reservoir and anastomotic sites in an orthotopic neobladder, their relative incidences and illustrate salient imaging points with case examples.