ABSTRACT
A non-selected group of 50 patients with recurrent herpetic keratitis, subclassified into groups of stromal or epithelial forms was typed for HLA-ABC antigens. In none of the groups was a statistically significant association to a certain HLA antigen found. When these data are combined with other reviewed reports on HLA types in recurrent herpetic keratitis, a statistically significant association between HLA-B5 and the whole group of recurrent herpetic keratitis, as well as between the subgroup of recurrent stromal keratitis, could be demonstrated. Recurrent epithelial keratitis showed an insignificant association to this antigen.
Subject(s)
HLA Antigens/analysis , Keratitis, Dendritic/immunology , HLA-A Antigens , HLA-B Antigens , HLA-C Antigens , HumansABSTRACT
Fourty-three eyes with active dendritic keratitis, nearly one third of which had failed to respond to other antiviral agents, were treated with acyclovir with or without preceding debridement. The patients were randomly selected. No statistical difference could be demonstrated between the 2 groups in terms of rate of healing or in efficacy of cure. Acyclovir also seemed to be effective in stromal corneal lesions. There were only minor side effects.
Subject(s)
Acyclovir/analogs & derivatives , Antiviral Agents/therapeutic use , Keratitis, Dendritic/drug therapy , Acyclovir/therapeutic use , Chloramphenicol/therapeutic use , Clinical Trials as Topic , Drug Therapy, Combination , Humans , Ophthalmic SolutionsABSTRACT
By means of an enzyme-linked immunosorbent assay (ELISA) antibodies to whole lens homogenate were found in 50.0% of 38 patients with senile cataract and in 57.3% of 75 controls. The antibody titres were in the range of 10-160 in both groups. IgG antibodies occurred in 44.7% of patients and in 45.3% of controls, whereas IgM antibodies were found in 21.1% of the patients and in 40.0% of the controls (not significant). Postoperative uveitis occurred in 5 (31.6%) of 19 patients, who had antibodies in serum prior to the operation and in only 2 (10.5%) of 19 antibody-negative patients (P = 0.10).
Subject(s)
Antibodies/analysis , Cataract Extraction , Cataract/immunology , Lens, Crystalline/immunology , Adult , Aged , Female , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Lens, Crystalline/injuries , Male , Middle Aged , Postoperative Complications/immunology , Uveitis/immunologyABSTRACT
HLA tissue-type antigen determination for A-, B- and C-antigens in 88 patients suffering from giant cell arteritis of the temporal artery showed no significant deviations as compared to a control material of 3164 blood donors. A weak indication of association with antigen HLA-B8 appeared to be of interest due to a corresponding indication in previous investigation. The patients were a mixed hospital material, consisting of cases of clinical temporal arteritis and patients with polymyalgia rheumatica. There was an overrepresentation of women (77%). Familial occurrence was demonstrated sporadically (3 pairs of siblings).
Subject(s)
Giant Cell Arteritis/immunology , HLA Antigens/analysis , Aged , Epitopes , Female , Giant Cell Arteritis/genetics , Humans , Male , Middle Aged , Phenotype , Polymyalgia Rheumatica/immunologyABSTRACT
The ultrastructure of the ant-egg cataractous lens has been studied. Comparison of tissue demineralized by means of EDTA with untreated tissue showed the calcium salts in the ant-eggs to be mostly crystalline. A laminar appearance of the ant-egg seen in EDTA treated material suggested an intermittent growth of the structure. In the ant-eggs, as well as in some areas separate from these, membrane limited cytoplasmic bodies could be seen in many cases, the membranes of which were partly joint and partly separated by an electron dense material. It is suggested that the calcifications seen as the ant-eggs are secondary phenomena to an abnormal metabolism, morphologically seen as membrane limited cytoplasmic bodies.
Subject(s)
Cataract/pathology , Lens, Crystalline/ultrastructure , Cataract/metabolism , Cell Membrane/ultrastructure , Cytoplasm/ultrastructure , Cytoplasmic Granules/ultrastructure , Edetic Acid/pharmacology , Humans , Lens, Crystalline/metabolism , Lens, Crystalline/pathologyABSTRACT
A family with "ant-egg" cataract in three generations is described. The cataract is congenital, probably of autosomal dominant inheritance. Light microscopy of the ant-eggs showed that they are made up of a peripheral zone of lens material and a large almost homogenous centre. Element analysis by X-ray spectrophotometry showed a high content of calcium and phosphorus in the centre. The cataract has been easy to operate on and the postoperative visual results have been good.
Subject(s)
Cataract/genetics , Calcium/analysis , Cataract/congenital , Cataract/pathology , Child , Child, Preschool , Female , Genes, Dominant , Histocytochemistry , Humans , Lens, Crystalline/metabolism , Lens, Crystalline/pathology , Male , Pedigree , Phosphorus/analysis , SpectrophotometryABSTRACT
For the first time the clinical effect of acetazolamide (AZA) in haemorrhagic glaucoma has been the subject of a controlled study. The clinical impression of none, or a slight effect of AZA in haemorrhagic glaucoma was confirmed. An intravenous injection of a AZA, 10 mg/kg body weight, produced in 13 patients (14 eyes) with haemorrhagic glaucoma a fall in the intraocular pressure (IOP) of only 7.7% within 30 min. A similar examination of 4 patients (5 eyes) with other types of glaucoma showed a drop in pressure of 32.0%. Examinations of the haemorrhagic-glaucoma eyes later that day and on the next day showed no further effect of AZA on the IOP. It is concluded that AZA is of no importance in the treatmen of haemorrhagic glaucoma.
