ABSTRACT
BACKGROUND: Central serous chorioretinopathy (CSC) is a condition that originates from alterations of the choroidal circulation. The aim of this paper was to evaluate the use of indocyanine green angiography (ICGA) in patients with chronic CSC. MATERIAL/METHODS: The analysis included 17 patients (34 eyes) with chronic CSC in at least 1 eye. The eye examination included: distance and near visual acuity, biomicroscopy, applanation tonometry, fundus examination, colored and red-free fundus photography, evaluation of autofluorescence, optical coherence tomography, and fluorescein and indocyanine green angiography. RESULTS: In 34 eyes (100%) involved in the ICGA study the results revealed zones of transient increased choroidal vessels permeability. In 18 eyes (52.9%) choroidal changes were accompanied by a focal serous pigment epithelial detachment. In 4 eyes (11.8%) of 3 patients' the ICGA examination confirmed the presence of occult choroidal neovascularization (CNV). In the patient with bilateral diffuse retinal pigment epitheliopathy, CNV was present in 1 eye, in the patient with unilateral chronic CSC it was also present in 1 eye, and in the third patient with bilateral chronic CSC it was detected in both eyes. CONCLUSIONS: ICGA is a very useful examination that enables ophthalmologists to visualize choroidal changes due to chronic CSC, as well as to diagnose occult CNV in chronic CSC.
Subject(s)
Angiography , Central Serous Chorioretinopathy/diagnosis , Indocyanine Green , Aged , Central Serous Chorioretinopathy/physiopathology , Female , Humans , Male , Middle Aged , Tomography, Optical Coherence , Tonometry, Ocular , Visual AcuityABSTRACT
Gemcitabine is a cytostatic drug from the pyrimidine antimetabolite group. It is used in treatment of some neoplasms, among them inoperable pancreatic cancer. The most common undesirable effects of gemcitabine include pancytopenia, with thrombocytopenia associated with gemcitabine's myelosuppressive activity. This study contains a description of six cases of patients with pancreatic cancer treated with gemcitabine, who - contrary to expectations - showed increased levels of thrombocytes. The number of thrombocytes ranged from 424 to 1059 × 109 (mean 470 × 109). It was highest during the 2(nd) and 3(rd) chemotherapy cycles and it normalized after completion of treatment. One patient suffered from a cardiac infarction on the 15(th) day of the 3(rd) cycle of treatment, despite a normal level of thrombocytes on the day; however, the patient indicated thrombocytosis on the 1(st) day of the cycle. No thromboembolic complications were observed in the remaining patients. These patients were not subjected to any antithrombotic prophylaxis. The mechanism by which thrombocytosis occurs after administration of gemcitabine and the clinical significance of this fact remain unknown.
ABSTRACT
PURPOSE: To evaluate long term results of phacoemulsification with PC IOL and capsular tension ring (CTR) implantation in lens subluxation. MATERIAL AND METHODS: The study comprised of 134 patients--146 eyes with subluxated lens. In all cases phacoemulsification with PC IOL and CTR implantation was performed. RESULTS: No intaroperative complications has occured. Postoperative complications included: inflammation in the anterior chamber in 3 eyes (2.1%), retinal detachment in 2 eyes (1.4%). In all cases there was no PC IOL decentration. CONCLUSIONS: (1) CTR facilitates phacoemulsification with PC IOL implantation in lens subluxation. (2) Phacoemulsification of subluxated lens with PC IOL and CTR implantation seems to be safe and effective procedure.
