[The 32P-incorporation into nucleic acids and adenosine phosphates of the rat brain after acute and chronic influence of meclofenoxate (author's transl)]. / 32P-Einbau in Nukleinsäuren und Adenosinphosphate des Rattengehirns nach akuter und chronischer Einwirkung von Meclofenoxat

Beta-Dimethylaminoethyl-p-chlorophenoxyacetate hydrochloride (meclofenoxate, Helfergin) was adminstered orally in dosages of 300 mg/kg 3 times during an 18-h period. The incorporation rate of the total and cytoplasmic RNA as well as of ATP, ADP and AMP decreased. Contradictory results were obtained after a 16-day treatment with orally 300 mg/kg per day: while the 32P-incorporation rate of the cytoplasmic RNA and the 3 adenosine phosphates increased, the nuclear RNA showed a correspondent diminishing. No changes of the ATP content could be observed in any group. The differences between the acute and chronic experiments could be explained by a different excitation of the animals and by the very different dosages. The increased 32P-incorporation into the cytoplasmic and into the adenosine phosphates in the chronic experiments are explained by a stimulation of the pentose phosphate shunt which yields mainly the phosphate group for the synthesis of AMP.

[The influence of naftidrofuryl on 32Pi-incorporation into nucleic acids and adenosine phosphates of the rat brain]. / Der einfluss von Naftidrofuryl auf den 32Pi-einbau in Nukleinsäuren und Adenosinphosphate des Rattengehirns

3-(1-Naphthyl)-2-tetrahydrofuryl-propionic acid-beta-diethylester-hydrogenoxalate (naftidrofuryl) increased after a 15-day treatment with orally 200 mg/kg per day the 32P-incorporation rate of two nucleic acid fractions and of ATP, ADP and AMP of rat brains. In contrast to the findings of other authors no increased ATP content was observed. The increased incorporation of the alpha-phosphate during the de novo synthesis of AMP.