1.
Org Lett
; 11(15): 3310-3, 2009 Aug 06.
Article
in English
| MEDLINE
| ID: mdl-19583199
ABSTRACT
The first example of diastereo- and enantioselective aza-MBH-type reaction was accomplished by the asymmetric synthesis of beta-nitro-gamma-enamines via a (1R,2R)-diaminocyclohexane thiourea derivative mediated tandem Michael addition and aza-Henry reaction in good yields (up to 95%) and high enantioselectivities (up to 91% ee) and diastereoselectivities (up to 1:99 dr).