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1.
Ann Urol (Paris) ; 40(4): 220-32, 2006 Aug.
Article in French | MEDLINE | ID: mdl-16970065

ABSTRACT

Injuries to anterior urethra are uncommon, mainly due to blunt trauma, and rarely associated with pelvic fractures or life threatening multiple lesions. Straddle type injury is the most frequent lesion, in which the immobile bulbar urethra is crushed or compressed on the inferior surface to the pubic symphysis. Diagnosis of urethral injury is easy, suspected due to trauma circumstances, presence of urethrorragy or initial hematuria, and eventually difficult micturition and penile scrotal for perineoscrotal hematoma. It should always be confirmed and classified by retrograde urethro-gram, realized either immediately or after a few days. Initial acute management is suprapubic cystostomy, if possible before any attempt of urethral catheterization or miction. Urethral contusions only require this urinary diversion or urethral catheter for a few days and usually heal without any sequelae. Management of partial and complete disruptions remains controversial: suprapubic diversion only and secondary endoscopic or open surgical repair of the urethral stricture that occurs in the great majority of the cases (always after complete disruption), early endoscopic realignment and prolonged urethral catheterization (4 for 8 weeks according to the lesion), in partial disruptions, more controversial in complete disruptions; delayed (after a few days) open surgical repair (urethrorraphy) that is the preferred European and French attitude for complete disruptions. Penetrating anterior urethral trauma and urethral lesions associated with penile fracture require immediate surgical exploration and repair if possible. After anterior urethral disruption, the main morbidity is urethral stricture very often requiring surgical treatment (visual urethrotomy if the structure is short, end to end spatulated urethrorraphy, flap or graft urethroplasty if longer).


Subject(s)
Urethra/injuries , Urethral Diseases/diagnosis , Urethral Diseases/surgery , Humans , Male , Treatment Outcome , Urethral Diseases/classification , Urethral Diseases/complications , Urethral Stricture/etiology , Urologic Surgical Procedures/methods , Wounds, Nonpenetrating/diagnosis , Wounds, Nonpenetrating/surgery , Wounds, Penetrating/diagnosis , Wounds, Penetrating/surgery
2.
Ann Pharm Fr ; 63(6): 429-32, 2005 Nov.
Article in French | MEDLINE | ID: mdl-16292235

ABSTRACT

cGMPs require that QA systems rely upon qualified personnel in charge of pharmaceutical operations. In order to achieve this legal requirement, the manufacturer must provide initial training and regular re-training along with periodical evaluations of their practical efficiency. This cGMP-learning multimedia CD-R is an interactive and individual training tool, designed for QC laboratory personnel. It contains a final questionnaire allowing an assessment of the course efficiency. Building up a ten-module teaching program entitled "Le médicament en toute confiance", the development of this CD-R was supervised by an European team of experienced industrial pharmacists.


Subject(s)
CD-I , Chemistry, Pharmaceutical/education , Drug Compounding/standards , Drug Industry/standards , Laboratories/standards , Quality Control , Humans
4.
Endoscopy ; 32(12): 956-62, 2000 Dec.
Article in English | MEDLINE | ID: mdl-11147944

ABSTRACT

BACKGROUND AND STUDY AIMS: How to approach common bile-duct (CBD) stones discovered during laparoscopic cholecystectomy (LC) is still a subject for debate. After sequential strategies, the natural trend is now towards single-stage therapy. The aim of this study was to establish the feasibility of intraoperative endoscopic sphincterotomy (IOES) when CBD stones are discovered or strongly suspected on intraoperative cholangiography (IOC) during LC. PATIENTS AND METHODS: Out of a total of 2193 laparoscopic cholecystectomies, we reviewed 57 patients who, between 1991 and 1999, underwent IOES just after LC during the same anesthetic session. Under fluoroscopic guidance, one group of 32 patients (Dijon) underwent IOES in the prone position and a second group of 25 patients (Poitiers) in the left lateral position. RESULTS: IOES was successful in all cases (100%). CBD stones were definitively found in 49 cases (86%) but retrieved or released into the duodenum after IOES in only 46 cases (46/49, 93.9%). The mean duration of the intraoperative endoscopic procedure was 28 minutes (range 15-75). The short-term complication rate was 7%. The mean postoperative hospital stay was 5.3 days (range 2-14). CONCLUSIONS: IOES performed after LC during the same anesthetic session is feasible with low risk and with good results. It offers the opportunity to treat in one stage both cholecystolithiasis and choledocholithiasis without the need for surgical CBD exploration.


Subject(s)
Gallstones/therapy , Intraoperative Care , Sphincterotomy, Endoscopic , Adolescent , Adult , Aged , Aged, 80 and over , Bile Duct Diseases , Feasibility Studies , Female , Humans , Male , Middle Aged , Sphincterotomy, Endoscopic/methods , Time Factors
5.
Appl Opt ; 39(34): 6430-5, 2000 Dec 01.
Article in English | MEDLINE | ID: mdl-18354656

ABSTRACT

Three-dimensional optical topometry of technical surfaces becomes increasingly important for the control of industrial processes. However, the local reflectance of the surface of the investigated sample often varies within a wide range, making accurate measurements by fringe projection difficult. We demonstrate the use of a liquid-crystal spatial light modulator as the fringe-generating element in a standard stereo microscope. With this device the brightness of the projected patterns can be adapted pixelwise. This technique leads to a significant improvement of the results of our measurements with a phase-shifting algorithm.

8.
Ann Pharm Fr ; 54(3): 131-9, 1996.
Article in French | MEDLINE | ID: mdl-8794583

ABSTRACT

At manufacturing, finished dosage forms must meet the 75/318/EEC Directive particularly the criteria defining the potency registered limits i.e. +/- 5% variation of their nominal contents in general except some cases where sound justification can be provided on the basis of experimental results obtained at 95% confidence level. The described statistical method allows calculation of release limits of potency of any dosage form and applies to any parameter for which the rate of change with time is predictably uniform and linear. Assurance is then provided at 95% confidence level that any lot showing a mean release assay result within the calculated release limits will remain within registered limits at any subsequent time within its shelf-life. On the basis of real quality profiles including dozens of lots, the authors explains that the use of this statistical method leads to an efficient retrospective validation technic by means of chemical analysis.


Subject(s)
Drug Labeling/statistics & numerical data , Pharmacokinetics , Pharmacology
9.
J Urol Nephrol (Paris) ; 82(6): 437-46, 1976 Jun.
Article in French | MEDLINE | ID: mdl-787552

ABSTRACT

Among the entero-urinary fistulae, the most frequent are those fistulae which unite the sigmoid colon and the bladder. Fistulae between the ureter and the colon are ecxeptional as only two spontaneous ureterocolic fistulae have been reported. With reference to one case, the authors review the different complementary examinations which enable making the diagnosis and discuss the therapeutic attitude, which differs depending on whether the kidney above the fistula is functional or not.


Subject(s)
Colonic Diseases/diagnosis , Intestinal Fistula/diagnosis , Ureteral Diseases/diagnosis , Urinary Fistula/diagnosis , Colonic Diseases/etiology , Colonic Diseases/surgery , Female , Humans , Intestinal Fistula/etiology , Intestinal Fistula/surgery , Middle Aged , Ureteral Diseases/etiology , Ureteral Diseases/surgery , Urinary Fistula/etiology , Urinary Fistula/surgery
11.
J Urol Nephrol (Paris) ; 81(6): 379-84, 1975 Jun.
Article in French | MEDLINE | ID: mdl-1152132

ABSTRACT

In a 25-year-old woman presenting with a right ureteric stenosis, the authors had the surprise to find at operation an extensive tumour of the small intestine. The tumour compressed the ureter and involved the common iliac, artery, requiring a complex surgical procedure with major vessel repair.


Subject(s)
Colonic Neoplasms/complications , Ileum , Intestinal Neoplasms/complications , Ureteral Obstruction/etiology , Adult , Angiography , Colonic Neoplasms/diagnosis , Colonic Neoplasms/surgery , Female , Humans , Ileum/surgery , Intestinal Neoplasms/diagnosis , Intestinal Neoplasms/surgery , Ureteral Obstruction/diagnostic imaging , Ureteral Obstruction/surgery , Urography
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