ABSTRACT
Polycystic kidney disease is the most common inherited disorder in cats. Renal cysts progressively increase in size and number, resulting in a gradual decrease in kidney function. An autosomal dominant mutation in exon 29 of the polycystin-1 gene has been identified, mostly in Persian and Persian-related breeds. This case study describes polycystic kidney disease in four British shorthair cats, of which two had the same genetic mutation reported in Persian and Persian-related cats. This likely reflects introduction of this mutation into the British shorthair breeding line because of previous outcrossing with Persian cats. An infected renal cyst was diagnosed and successfully treated in one of the cats. This is a commonly reported complication in human polycystic kidney disease, and to the authors' knowledge has not previously been reported in cats with polycystic kidney disease.
Subject(s)
Cat Diseases/diagnosis , Polycystic Kidney Diseases/veterinary , Animals , Anti-Bacterial Agents/therapeutic use , Breeding , Cat Diseases/drug therapy , Cat Diseases/genetics , Cats , Diagnosis, Differential , England , Escherichia coli Infections/complications , Escherichia coli Infections/drug therapy , Escherichia coli Infections/veterinary , Female , Male , Polycystic Kidney Diseases/diagnosis , Polycystic Kidney Diseases/genetics , Urinalysis/veterinaryABSTRACT
BACKGROUND: Information regarding acute kidney injury (AKI) in cats is limited, and there are no reliable tools to objectively assess disease severity and predict outcome. OBJECTIVES: To assess clinical signs, clinicopathologic abnormalities, etiology, and outcome of cats with AKI, and to develop models using clinical metrics and empirically derived scores to predict outcome. ANIMALS: One hundred and thirty-two client-owned cats. METHODS: Retrospective study. Bivariate logistic regression analyses were performed to identify variables predictive of 30-day survival. Continuous variables outside the reference range were divided into quartiles to yield quartile-specific odds ratios (OR) for survival. Models were developed incorporating weighting factors assigned to each quartile based on the OR. A predictive score for each model was calculated for each cat by summing all weighting factors. A second, multivariable logistic regression model was created from actual values of the same variables. Receiver operating characteristic curve analyses were performed to determine the models' performance. Models were further tested using a subset of cases not used in initial assessment. RESULTS: Fifty five of 132 cats (42%) remained dialysis-independent for at least 30 days after discharge, and the remaining 77 cats either died (n = 37, 28%) or were euthanized (n = 40, 30%). The most common etiology was ureteral obstruction (n = 46, 35%). Higher scores were associated with decreased probability of survival (P < .001). Models correctly classified outcomes in 75-77% of the cases and 84-89% of the cases in the subsequent evaluation. CONCLUSIONS AND CLINICAL IMPORTANCE: Models can provide objective guidance in assessing AKI prognosis and severity, but should be validated in other cohorts of cats.
