ABSTRACT
The ultradispersed piezoceramic powder containing lead oxides, zirconium, titanium, bismuth, cadmium, manganese, strontium, and chromium was tested for its effect on the health status of the staff serving pilot industrial units producing the powder. There was a significant increase in the incidence of digestive disease, a tendency for respiratory and osteomuscular diseases to increase. It is concluded that it is necessary to use individual means of the protection and prophylaxis of the observed diseases.
Subject(s)
Ceramics/adverse effects , Health Status , Occupational Diseases/etiology , Catchment Area, Health , Female , Humans , Male , Middle Aged , Russia/epidemiologyABSTRACT
In albino rats subjected to chronic inhalation of ultradispersed piezoceramic powder, scanning electron microscopy revealed changes in membrane surface of peripheral blood erythrocytes manifested as decreased number of diskocytes and increased number of transitional, prehemolytic, and degenerating forms. These parameters returned to normal 1 month after termination of inhalations.
Subject(s)
Administration, Inhalation , Ceramics , Erythrocytes/drug effects , Erythrocytes/ultrastructure , Powders , Animals , Male , Microscopy, Electron , Microscopy, Electron, Scanning , Rats , Time FactorsABSTRACT
Energy metabolism was studied in poisoned rat liver tissue after application of sapropel lipid extracts and its fractions. Total extract and its polar fraction affected distinctly the energy metabolism and ultrastructure of hepatocytes. The restoring influence of sapropel lipids appears to occur due to both their chemical composition and adaptogenic effect on intracellular reparation.
Subject(s)
Benzopyrans/therapeutic use , Carbon Tetrachloride Poisoning/metabolism , Energy Metabolism , Humic Substances/therapeutic use , Lipids/therapeutic use , Liver/metabolism , Mud Therapy , Animals , Carbon Tetrachloride Poisoning/therapy , Chemical and Drug Induced Liver Injury/therapy , Chromatography, Liquid , Liver/ultrastructure , Male , Microscopy, Electron , Rats , Rats, Inbred StrainsABSTRACT
Reparative and bioregulatory properties of total lipids extracted from sapropel were studied in experimental chemical toxic hepatitis. The extract exhibited a combined antioxidant and bioregulatory effect on hepatic lesions. This finding permitted the total lipid sapropel extract to be suggested as a bioactive corrector of chemical hepatic intoxication.
Subject(s)
Benzopyrans/therapeutic use , Carbon Tetrachloride Poisoning/therapy , Chemical and Drug Induced Liver Injury/therapy , Humic Substances/therapeutic use , Lipids/therapeutic use , Liver/drug effects , Mud Therapy/methods , Animals , Carbon Tetrachloride Poisoning/metabolism , Chemical and Drug Induced Liver Injury/etiology , Chemical and Drug Induced Liver Injury/metabolism , Drug Evaluation, Preclinical , Histocytochemistry , Liver/metabolism , Male , Rats , Rats, Inbred StrainsABSTRACT
The biological activity of polar and non-polar lipid fractions obtained from silt mud has been studied. It has been shown in rats with experimental exudative peritonitis that phonophoresis of the polar fraction has pronounced anti-inflammatory, stimulant and resolving effects. The non-polar hexane-soluble fraction has been found to be biologically inactive despite the presence of carotene.